Jaiswal Piyush, Gidwani Bina, Vyas Amber
a University Institute of Pharmacy, Pt. Ravishankar Shukla University , Raipur, Chhattisgarh , India.
Artif Cells Nanomed Biotechnol. 2016;44(1):27-40. doi: 10.3109/21691401.2014.909822. Epub 2014 May 9.
In the last few decades, various drug-delivery technologies have emerged and a fascinating part of this has been the development of nanoscale drug delivery devices. Nanoparticles (NPs) and other colloidal drug-delivery systems modify the kinetics, drug distribution in the body and release profile of an associated drug. Nanostructured lipid carriers (NLCs) have been reported to be an alternative system to emulsions, liposomes, microparticles, solid lipid nanoparticles (SLNs) and their polymeric counterparts due to their numerous advantages. This paper basically reviews the types of NLCs, mechanism of skin penetration, stability related issues along with their production techniques, characterisation and applications towards targeted drug delivery.
在过去几十年中，各种药物递送技术不断涌现，其中一个引人入胜的领域是纳米级药物递送装置的发展。纳米颗粒（NPs）和其他胶体药物递送系统改变了相关药物的动力学、体内药物分布和释放曲线。据报道，纳米结构脂质载体（NLCs）由于其众多优点，是乳液、脂质体、微粒、固体脂质纳米颗粒（SLNs）及其聚合物对应物的替代系统。本文主要综述了NLCs的类型、皮肤渗透机制、稳定性相关问题以及它们的生产技术、表征和靶向药物递送应用。
