Cortez Melissa M, Wilder Michael J, McFadden Molly, Majersik Jennifer J
Department of Neurology, University of Utah, Salt Lake City, UT; Department of Neurology, Mayo Clinic, Scottsdale, AZ.
Department of Neurology, University of Utah, Salt Lake City, UT.
J Stroke Cerebrovasc Dis. 2014 Aug;23(7):1890-6. doi: 10.1016/j.jstrokecerebrovasdis.2014.02.012. Epub 2014 May 9.
Few data exist about health-related quality of life outcomes after intra-arterial therapy (IAT) for acute ischemic stroke (AIS). We assessed stroke-specific quality of life (SS-QOL) in survivors of stroke after IAT. Consecutive patients undergoing IAT for AIS from 2005 to 2010 were retrospectively identified via an institutional database. SS-QOL (using the SS-QOL score) and disability status (modified Rankin Scale [mRS]) were prospectively assessed via mailed questionnaire. We analyzed quality of life (QOL) scores by domain and summary score, with a summary score of 4 or more defined as a good outcome. Analysis of variance (ANOVA) was used to model the effect of final recanalization status, stroke severity, and mRS on total QOL score. ANOVA and Pearson correlations were used to test the association between stroke severity/mRS and QOL/time since stroke, respectively. Of 99 patients with AIS, 61 responded, yielding 11 interim deaths, 7 incomplete surveys, and 43 complete surveys for analysis. Among responding survivors, overall QOL score was 3.9 (standard deviation 0.7); 77% of these reported good QOL. Scores were higher in recanalized patients in 11 of 12 domains but was significant only for mood. Although mRS was associated with stroke severity, QOL was independent of both. Seventy-seven percent of survivors of AIS who received IAT reported good QOL. Furthermore, these data suggest that SS-QOL is an independent outcome from stroke severity and disability status.
关于急性缺血性卒中（AIS）动脉内治疗（IAT）后与健康相关的生活质量结果的数据很少。我们评估了IAT后卒中幸存者的卒中特异性生活质量（SS-QOL）。通过机构数据库对2005年至2010年接受AIS的IAT的连续患者进行回顾性识别。通过邮寄问卷前瞻性评估SS-QOL（使用SS-QOL评分）和残疾状态（改良Rankin量表[mRS]）。我们按领域和总结评分分析生活质量（QOL）评分，总结评分为4或更高定义为良好结局。方差分析（ANOVA）用于模拟最终再通状态、卒中严重程度和mRS对总QOL评分的影响。ANOVA和Pearson相关性分别用于检验卒中严重程度/mRS与QOL/卒中后时间之间的关联。在99例AIS患者中，61例有回应，产生11例中期死亡、7例不完整调查和43例完整调查用于分析。在有回应的幸存者中，总体QOL评分为3.9（标准差0.7）；其中77%报告生活质量良好。在12个领域中的11个领域，再通患者的评分更高，但仅情绪领域有统计学意义。尽管mRS与卒中严重程度相关，但QOL与两者均无关。接受IAT的AIS幸存者中有77%报告生活质量良好。此外，这些数据表明SS-QOL是独立于卒中严重程度和残疾状态的结局。
