Lau Frank H, Pomahac Bohdan
Division of Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
Wound Repair Regen. 2014 May;22 Suppl 1:14-7. doi: 10.1111/wrr.12165.
Fascial healing following acute injury, such as that occurring during surgical procedures, is defined functionally. For example, failure of fascial healing following celiotomy is only identified when incisional hernias are diagnosed. Such hernias incur billions of dollars per year in medical costs. Despite the importance of fascial healing, there is a paucity of data regarding the quality such healing. In clinical settings, the quantification of fascial wound healing is limited to a binary state: either there is no clinically apparent functional deficit and full fascia healing is assumed, or an incisional hernia or other functional failure is visible and the fascia did not heal. There are no clinical methods to isolate and functionally test fascia in patients. Recent studies have revealed unexpected findings regarding the recovery of tensile strength, specific surgical methods that optimize fascial healing, and the potential impact of biological pharmaceuticals in eliminating fascial healing failure. However, much remains unknown about the biology of fascial healing.
急性损伤（如手术过程中发生的损伤）后的筋膜愈合是从功能角度来定义的。例如，只有在诊断出切口疝时，才会确定剖腹手术后筋膜愈合失败。此类疝每年产生数十亿美元的医疗费用。尽管筋膜愈合很重要，但关于这种愈合质量的数据却很少。在临床环境中，筋膜伤口愈合的量化仅限于二元状态：要么没有明显的临床功能缺陷，假定筋膜完全愈合；要么可见切口疝或其他功能衰竭，表明筋膜未愈合。目前尚无临床方法对患者的筋膜进行分离和功能测试。最近的研究揭示了关于拉伸强度恢复、优化筋膜愈合的特定手术方法以及生物药物在消除筋膜愈合失败方面的潜在影响等意外发现。然而，关于筋膜愈合的生物学仍有许多未知之处。
