Prima Heryu, Sofii Imam, Fauzi Aditya Rifqi, Dachlan Ishandono
Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.
Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.
BMC Res Notes. 2020 Oct 30;13(1):502. doi: 10.1186/s13104-020-05349-y.
Incisional hernia is a frequent complication of midline laparotomy. The suturing technique is an important determinant of the risk of developing an incisional hernia. Moreover, IL-6 has crucial roles in the wound-healing process. We aimed to compare the large stitch vs. small stitch technique for abdominal fascial closure on IL-6 expressions in rats.
Twenty rats were used. The small stitch group received small tissue bites of 5 mm and the large stitch group received large bites of 10 mm. The incisions of fascia were closed by running sutures. Animals were euthanized on days 4 and 7. Histological sections of the tissue-embedded sutures were analyzed for IL-6 expressions. Two-way ANOVA showed that rats in the small stitch group had similar IL-6 expressions on days 4 and 7 to those in the large stitch group (p = 0.36). In conclusion, the IL-6 expressions are similar between the small and the large stitch groups, implying that different suturing techniques might not have an impact on the incisional hernia occurrence.
切口疝是中线剖腹手术常见的并发症。缝合技术是发生切口疝风险的重要决定因素。此外，白细胞介素-6（IL-6）在伤口愈合过程中起关键作用。我们旨在比较大鼠腹部筋膜闭合的大针距与小针距技术对IL-6表达的影响。
使用了20只大鼠。小针距组采用5毫米的小组织咬合，大针距组采用10毫米的大咬合。筋膜切口采用连续缝合关闭。在第4天和第7天对动物实施安乐死。对包埋组织的缝线的组织学切片进行IL-6表达分析。双向方差分析显示，小针距组大鼠在第4天和第7天的IL-6表达与大针距组相似（p = 0.36）。总之，小针距组和大针距组之间的IL-6表达相似，这意味着不同的缝合技术可能对切口疝的发生没有影响。
