Sofii Imam, Dipoyono Wisnu, Prima Heryu, Sari Yessy Martha, Fauzi Aditya Rifqi
Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.
Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia.
Ann Med Surg (Lond). 2020 Oct 23;60:106-109. doi: 10.1016/j.amsu.2020.10.033. eCollection 2020 Dec.
Incisional hernia is a frequent complication of abdominal wall incision and has a high rate of recurrence. Most of the studies stated that non-absorbable sutures decreased incisional hernia incidences, but some stated otherwise. We aimed to compare the ratio between monofilament non-absorbable sutures and multifilament absorbable sutures for abdominal fascia closure in Wistar albino rats.
Forty rats were divided into four groups. Groups 1 and 3 were sutured with monofilament non-absorbable (). Groups 2 and 4 were sutured with multifilament absorbable (). Then, groups 1 and 2 were euthanized on day 4 (POD 4), while groups 3 and 4 were euthanized on day 7 (POD 7). Samples of fascia (1 × 0.5 cm) were taken for analysis. ratios were measured using immunohistochemistry staining methods.
While the expression of was not significantly different between monofilament non-absorbable and multifilament absorbable at POD 4 and 7 ( = 0.45 and 0.81, respectively), the expression of reached a significant level with -values of 0.0003 and 0.0004 for POD 4 and 7, respectively. Moreover, the ratio was also significantly different between the two groups either at POD 4 (0.88 ± 0.23 0.53 ± 0.08; = 0.0003) and 7 (1.77 ± 0.65 1.03 ± 0.28; = 0.004).
Monofilament non-absorbable sutures show a significantly higher ratio than multifilament absorbable sutures for abdominal fascia closure in rats. Our findings imply that the usage of monofilament non-absorbable sutures might have a beneficial effect on decreasing the incisional hernia occurrence.
切口疝是腹壁切口常见的并发症，复发率高。大多数研究表明，不可吸收缝线可降低切口疝的发生率，但也有一些研究得出了相反的结论。我们旨在比较单丝不可吸收缝线和多丝可吸收缝线在Wistar白化大鼠腹壁筋膜闭合中的比例。
将40只大鼠分为四组。第1组和第3组用单丝不可吸收缝线缝合。第2组和第4组用多丝可吸收缝线缝合。然后，第1组和第2组在术后第4天（POD 4）安乐死，而第3组和第4组在术后第7天（POD 7）安乐死。取筋膜样本（1×0.5 cm）进行分析。使用免疫组织化学染色方法测量比例。
虽然在POD 4和7时，单丝不可吸收缝线和多丝可吸收缝线之间的表达无显著差异（分别为=0.45和0.81），但在POD 4和7时，的表达分别达到显著水平，P值分别为0.0003和0.0004。此外，两组在POD 4（0.88±0.23对0.53±0.08；=0.0003）和7（1.77±0.65对1.03±0.28；=0.004）时的比例也有显著差异。
在大鼠腹壁筋膜闭合中，单丝不可吸收缝线的比例显著高于多丝可吸收缝线。我们的研究结果表明，使用单丝不可吸收缝线可能对降低切口疝的发生有有益作用。
需注意，原文中部分内容缺失具体名称，翻译时保留了原文格式。
