Department of Computer Science, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea.
School of Information and Communications, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 500-712, Republic of Korea.
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W416-21. doi: 10.1093/nar/gku368. Epub 2014 May 9.
In order to identify genes that are involved in oncogenesis and to understand how such genes affect cancers, abnormal gene expressions in cancers are actively studied. For an efficient access to the results of such studies that are reported in biomedical literature, the relevant information is accumulated via text-mining tools and made available through the Web. However, current Web tools are not yet tailored enough to allow queries that specify how a cancer changes along with the change in gene expression level, which is an important piece of information to understand an involved gene's role in cancer progression or regression. OncoSearch is a Web-based engine that searches Medline abstracts for sentences that mention gene expression changes in cancers, with queries that specify (i) whether a gene expression level is up-regulated or down-regulated, (ii) whether a certain type of cancer progresses or regresses along with such gene expression change and (iii) the expected role of the gene in the cancer. OncoSearch is available through http://oncosearch.biopathway.org.
为了鉴定参与肿瘤发生的基因，并了解这些基因如何影响癌症，人们积极研究癌症中的异常基因表达。为了高效获取生物医学文献中报告的此类研究结果，通过文本挖掘工具来积累相关信息，并通过网络提供。然而，目前的网络工具还不够灵活，无法支持指定查询，即指定癌症如何随着基因表达水平的变化而变化，这是了解相关基因在癌症进展或消退中作用的重要信息。OncoSearch 是一个基于网络的引擎，用于在 Medline 摘要中搜索提到癌症中基因表达变化的句子，查询指定（i）基因表达水平是上调还是下调，（ii）某种类型的癌症是否随着这种基因表达变化而进展或消退，以及（iii）该基因在癌症中的预期作用。OncoSearch 可通过 http://oncosearch.biopathway.org 获得。
