School of Information and Communications, Gwangju Institute of Science and Technology, 123 Cheomdangwagi-ro, Buk-go, Gwangju 500-712, Republic of Korea.
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W510-7. doi: 10.1093/nar/gkt531. Epub 2013 Jun 12.
Biological events such as gene expression, regulation, phosphorylation, localization and protein catabolism play important roles in the development of diseases. Understanding the association between diseases and genes can be enhanced with the identification of involved biological events in this association. Although biological knowledge has been accumulated in several databases and can be accessed through the Web, there is no specialized Web tool yet allowing for a query into the relationship among diseases, genes and biological events. For this task, we developed DigSee to search MEDLINE abstracts for evidence sentences describing that 'genes' are involved in the development of 'cancer' through 'biological events'. DigSee is available through http://gcancer.org/digsee.
生物事件,如基因表达、调控、磷酸化、定位和蛋白质降解等,在疾病的发生发展中起着重要作用。通过识别该关联中涉及的生物事件,可以更好地理解疾病与基因之间的关系。尽管在几个数据库中积累了生物学知识,并且可以通过网络访问这些知识,但目前还没有专门的网络工具允许查询疾病、基因和生物事件之间的关系。为此,我们开发了 DigSee,用于在 MEDLINE 摘要中搜索描述“基因”通过“生物事件”参与“癌症”发生发展的证据句。DigSee 可通过 http://gcancer.org/digsee 使用。