Department of Chemical Engineering, Boğaziçi University, 34342 Bebek, Sarıyer, İstanbul, Turkey.
Bioinformatics. 2013 May 15;29(10):1357-8. doi: 10.1093/bioinformatics/btt137. Epub 2013 Mar 20.
Knowledge of pathogen-host protein interactions is required to better understand infection mechanisms. The pathogen-host interaction search tool (PHISTO) is a web-accessible platform that provides relevant information about pathogen-host interactions (PHIs). It enables access to the most up-to-date PHI data for all pathogen types for which experimentally verified protein interactions with human are available. The platform also offers integrated tools for visualization of PHI networks, graph-theoretical analysis of targeted human proteins, BLAST search and text mining for detecting missing experimental methods. PHISTO will facilitate PHI studies that provide potential therapeutic targets for infectious diseases.
Supplementary data are available at Bioinformatics online.
为了更好地理解感染机制，需要了解病原体-宿主蛋白相互作用的知识。病原体-宿主相互作用搜索工具（PHISTO）是一个可通过网络访问的平台，提供有关病原体-宿主相互作用（PHI）的相关信息。它可以访问所有具有与人类实验验证的蛋白质相互作用的病原体类型的最新 PHI 数据。该平台还提供了用于可视化 PHI 网络、目标人类蛋白质的图论分析、BLAST 搜索和文本挖掘以检测缺失的实验方法的集成工具。PHISTO 将促进提供传染病潜在治疗靶点的 PHI 研究。
补充数据可在“Bioinformatics”在线获取。
