Scholten I, Custers I M, Moolenaar L M, Flierman P A, Cox T, Gianotten J, Hompes P G A, van der Veen F, Mol B W J
Centre for Reproductive Medicine, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands.
Centre for Reproductive Medicine, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands.
Reprod Biomed Online. 2014 Jul;29(1):125-30. doi: 10.1016/j.rbmo.2014.03.012. Epub 2014 Apr 4.
A previous randomized clinical trial compared immobilization for 15 min with immediate mobilization subsequent to intrauterine insemination (IUI) and showed higher ongoing pregnancy rates in couples immobilizing subsequent to IUI. The current study compared the long-term effectiveness of immobilization subsequent to IUI. All couples (n = 391) included in the trial were followed for 3 years after randomization and pregnancies and treatments were recorded. After the initial trial period, couples in both groups were offered treatment according to local protocol. The primary outcome was an ongoing pregnancy during the 3 years after the initial trial. In this time period, there were 143 ongoing pregnancies in the immobilization group (n = 199 couples) and 112 ongoing pregnancies in the immediate mobilization group (n = 192). The ongoing pregnancy rates were 72% and 58%, respectively (relative risk 1.2, 95% CI 1.1-1.4). The persistent significant difference in ongoing pregnancy rates underpins the importance of immobilization after IUI. There is no valid reason to withhold women from immobilizing for 15 min after IUI.
一项先前的随机临床试验比较了宫内人工授精（IUI）后固定15分钟与立即活动的效果，结果显示IUI后固定的夫妇持续妊娠率更高。本研究比较了IUI后固定的长期效果。试验纳入的所有夫妇（n = 391）在随机分组后随访3年，并记录妊娠和治疗情况。在初始试验期后，两组夫妇均按照当地方案接受治疗。主要结局是初始试验后3年内的持续妊娠。在此期间，固定组（n = 199对夫妇）有143例持续妊娠，立即活动组（n = 192）有112例持续妊娠。持续妊娠率分别为72%和58%（相对风险1.2，95%可信区间1.1 - 1.4）。持续妊娠率的持续显著差异证实了IUI后固定的重要性。没有合理的理由不让女性在IUI后固定15分钟。
