Dudek Katarzyna, Bednarek Dariusz, Ayling Roger D, Szacawa Ewelina
Department of Cattle and Sheep Diseases, National Veterinary Research Institute, Pulawy, Poland.
Mycoplasma Group, Animal Health and Veterinary Laboratories Agency (Weybridge), Woodham Lane, Addlestone, Surrey KT15 3NB, UK.
Res Vet Sci. 2014 Aug;97(1):32-7. doi: 10.1016/j.rvsc.2014.04.005. Epub 2014 Apr 23.
The effect of vaccinating pregnant cows with an inactivated vaccine against Mannheimia haemolytica, BRSV and PI3V infections on selected immune responses in their offspring was examined. Blood samples were collected weekly for 12 weeks from six newborn calves from each of vaccinated (experimental) and unvaccinated (control) dams. Specific antibodies to M. haemolytica, BRSV and PI3V and mean values of IgA, IgG concentrations were significantly higher in the experimental calves compared with the controls. However, specific antibody titres to adenovirus type 3, BHV1 and BVDV in the experimental calves had constant levels while the control group levels changed. The IgM, Hp and SAA concentrations generally increased until week 8 in the experimental group, but the control group titres became higher after week 9. This study demonstrates that specific immunisation of cows pre-partum significantly stimulated parameters associated with immunity and it also controlled the acute phase response intensity in their offspring. Therefore the vaccination of dams may provide additional antibody protection against infection to their offspring.
研究了用针对溶血曼氏杆菌、牛呼吸道合胞病毒（BRSV）和牛副流感病毒3型（PI3V）感染的灭活疫苗对怀孕母牛进行免疫接种，对其后代特定免疫反应的影响。从接种疫苗（实验组）和未接种疫苗（对照组）的母牛所生的六头新生犊牛中，每周采集血样，持续12周。与对照组相比，实验组犊牛针对溶血曼氏杆菌、BRSV和PI3V的特异性抗体以及IgA、IgG浓度的平均值显著更高。然而，实验组犊牛针对3型腺病毒、牛疱疹病毒1型（BHV1）和牛病毒性腹泻病毒（BVDV）的特异性抗体滴度保持恒定，而对照组的水平则发生了变化。实验组中，IgM、触珠蛋白（Hp）和血清淀粉样蛋白A（SAA）浓度通常在第8周前升高，但对照组的滴度在第9周后更高。本研究表明，母牛产前进行特异性免疫显著刺激了与免疫相关的参数，并且还控制了其后代的急性期反应强度。因此，给母牛接种疫苗可能为其后代提供额外的抗感染抗体保护。
