Troyanovsky S M, Guelstein V I, Tchipysheva T A, Krutovskikh V A, Bannikov G A
All-Union Cancer Research Center, USSR Academy of Medical Sciences, Moscow.
J Cell Sci. 1989 Jul;93 ( Pt 3):419-26. doi: 10.1242/jcs.93.3.419.
By immunomorphology, using keratin 17-specific monoclonal antibody, it has been shown that this keratin is expressed only in the basal cells of a group of complex epithelia: glandular epithelium with myoepithelial component, transitional and pseudostratified epithelia. Immunolocalization of keratin 17 provides evidence that the expression of this keratin strongly depends on the cell position within epithelial structures. The topographical character of the keratin expression suggests that these proteins may be implicated in the generation of spatial organization of epithelial tissues.
通过免疫形态学方法，使用角蛋白17特异性单克隆抗体，已证实这种角蛋白仅在一组复层上皮的基底细胞中表达：具有肌上皮成分的腺上皮、移行上皮和假复层上皮。角蛋白17的免疫定位提供了证据，表明这种角蛋白的表达强烈依赖于上皮结构内的细胞位置。角蛋白表达的拓扑学特征表明，这些蛋白质可能与上皮组织空间组织的形成有关。
