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新生儿血细胞比容变异性对血液纵向弛豫时间的影响:对动脉自旋标记磁共振成像的启示。

Impact of neonate haematocrit variability on the longitudinal relaxation time of blood: Implications for arterial spin labelling MRI.

作者信息

De Vis J B, Hendrikse J, Groenendaal F, de Vries L S, Kersbergen K J, Benders M J N L, Petersen E T

机构信息

Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Department of Neonatology, University Medical Center Utrecht, Utrecht, The Netherlands.

出版信息

Neuroimage Clin. 2014 Mar 19;4:517-25. doi: 10.1016/j.nicl.2014.03.006. eCollection 2014.

Abstract

BACKGROUND AND PURPOSE

The longitudinal relaxation time of blood (T 1b) is influenced by haematocrit (Hct) which is known to vary in neonates. The purpose of this study was threefold: to obtain T 1b values in neonates, to investigate how the T 1b influences quantitative arterial spin labelling (ASL), and to evaluate if known relationships between T 1b and haematocrit (Hct) hold true when Hct is measured by means of a point-of-care device.

MATERIALS AND METHODS

One hundred and four neonates with 120 MR scan sessions (3 T) were included. The T 1b was obtained from a T 1 inversion recovery sequence. T 1b-induced changes in ASL cerebral blood flow estimates were evaluated. The Hct was obtained by means of a point-of-care device. Linear regression analysis was used to investigate the relation between Hct and MRI-derived R1 of blood (the inverse of the T 1b).

RESULTS

Mean T 1b was 1.85 s (sd 0.2 s). The mean T 1b in preterm neonates was 1.77 s, 1.89 s in preterm neonates scanned at term-equivalent age (TEA) and 1.81 s in diseased neonates. The T 1b in the TEA was significantly different from the T 1b in the preterm (p < 0.05). The change in perfusion induced by the T 1b was -11% (sd 9.1%, p < 0.001). The relation between arterial-drawn Hct and R1b was R1b = 0.80 × Hct + 0.22, which falls within the confidence interval of the previously established relationships, whereas capillary-drawn Hct did not correlate with R1b.

CONCLUSION

We demonstrated a wide variability of the T 1b in neonates and the implications it could have in methods relying on the actual T 1b as for instance ASL. It was concluded that arterial-drawn Hct values obtained from a point-of-care device can be used to infer the T 1b whereas our data did not support the use of capillary-drawn Hct for T 1b correction.

摘要

背景与目的

血液的纵向弛豫时间(T1b)受血细胞比容(Hct)影响,已知新生儿的血细胞比容会有所变化。本研究有三个目的:获取新生儿的T1b值,研究T1b如何影响定量动脉自旋标记(ASL),以及评估当通过即时检测设备测量血细胞比容时,T1b与血细胞比容(Hct)之间的已知关系是否成立。

材料与方法

纳入104例接受120次磁共振扫描(3T)的新生儿。T1b通过T1反转恢复序列获得。评估T1b引起的ASL脑血流量估计值的变化。血细胞比容通过即时检测设备获得。采用线性回归分析研究血细胞比容与磁共振成像得出的血液R1(T1b的倒数)之间的关系。

结果

平均T1b为1.85秒(标准差0.2秒)。早产儿的平均T1b为1.77秒,足月等效年龄(TEA)扫描的早产儿为1.89秒,患病新生儿为1.81秒。TEA时的T1b与早产儿的T1b有显著差异(p < 0.05)。T1b引起的灌注变化为-11%(标准差9.1%,p < 0.001)。动脉抽取的血细胞比容与R1b的关系为R1b = 0.80×Hct + 0.22,该结果在先前建立的关系的置信区间内,而毛细血管抽取的血细胞比容与R1b无相关性。

结论

我们证明了新生儿T1b的广泛变异性及其对依赖实际T1b的方法(如ASL)可能产生的影响。得出的结论是,从即时检测设备获得的动脉抽取的血细胞比容值可用于推断T1b,而我们的数据不支持使用毛细血管抽取的血细胞比容进行T1b校正。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb52/3984444/2e0d263727d6/gr1.jpg

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