一种想抓挠的痒感。
An itch to be scratched.
机构信息
The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Neuron. 2010 Nov 4;68(3):334-9. doi: 10.1016/j.neuron.2010.10.018.
Abstract
The description of itch (formally known as pruritus) as an "unpleasant sensation that elicits the desire or reflex to scratch" (Ikoma et al., 2006) is immediately familiar. Research in the field of pruritoception has added to our understanding of this area of sensory neurobiology as it pertains to both normal and pathological conditions. In particular, much progress has been made on the mechanisms and circuits of itch, which we review here.
摘要
瘙痒（正式名称为瘙痒）的描述为“一种不愉快的感觉，会引起搔抓的欲望或反射”（Ikoma 等人，2006 年），这是立即熟悉的。瘙痒感觉传入的研究增加了我们对这一感觉神经生物学领域的理解，包括正常和病理条件。特别是，在瘙痒的机制和回路方面已经取得了很大的进展，我们在这里对此进行综述。
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本文引用的文献
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VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.伤害感受器中 VGLUT2 依赖性谷氨酸释放对于感知疼痛和抑制瘙痒是必需的。
Neuron. 2010 Nov 4;68(3):543-56. doi: 10.1016/j.neuron.2010.09.008.
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VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch.TRPV1 群体中 VGLUT2 依赖性感觉神经元调节疼痛和瘙痒。
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Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.感觉神经元特异性 G 蛋白偶联受体 Mrgprs 是介导氯喹诱导瘙痒的受体。
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Cellular basis of itch sensation.瘙痒感觉的细胞基础。
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Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch.组胺和/或 PAR-2 激动剂对小鼠浅层背角神经元的兴奋作用：在瘙痒中的潜在作用。
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