Gel'shteĭn V I, Chipysheva T A, Ermilova V D, Bannikov G A
Arkh Patol. 1989;51(10):28-35.
In the normal salivary gland, the monoclonal antibody to keratin 8 immuno-morphologically identifies the epithelium that covers acini and ducts. The monoclonal antibodies to keratin 17 and vimentin detect normal myoepithelium. The two keratins are found both in the epithelioid and mesenchyma-like components of pleomorphic adenoma, suggesting a single epithelial nature of this tumor. In all the morphological components of the pleomorphic adenoma, there are cells that combine protein expression of intermediate filaments normally labelling different cell subpopulations. This fact provides support for the hypothesis that the pleomorphic adenoma originates from bipotent precursor cells. A particular phenotype of pleomorphic adenoma elements is realized under the control of the local density of cells and microenvironment, as a result of which the cells expressing vimentin predominate in the mesenchymal component, keratin 8 in the epithelial tubular one.
在正常唾液腺中，角蛋白8单克隆抗体通过免疫形态学鉴定覆盖腺泡和导管的上皮。角蛋白17和波形蛋白单克隆抗体可检测正常肌上皮。这两种角蛋白在多形性腺瘤的上皮样和间充质样成分中均有发现，提示该肿瘤具有单一的上皮性质。在多形性腺瘤的所有形态学成分中，都存在一些细胞，它们结合了通常标记不同细胞亚群的中间丝蛋白表达。这一事实为多形性腺瘤起源于双能前体细胞的假说提供了支持。多形性腺瘤成分的特定表型是在细胞局部密度和微环境的控制下实现的，结果是波形蛋白表达细胞在间充质成分中占主导，角蛋白8在上皮管状成分中占主导。
