Chiarenza A, Elverdin J C, Espinal E, Giglio M J
Department of Physiology, University of Buenos Aires, Faculty of Odontology, Argentina.
Arch Oral Biol. 1989;34(12):999-1002. doi: 10.1016/0003-9969(89)90059-9.
The effects of sub-chronic cadmium (Cd) administration on the structure and subsequent secretory responses of the submaxillary and parotid glands to sialagogues were investigated. Female Wistar rats were injected subcutaneously with cadmium chloride (3.0 mg/kg body weight), 4 times a week for 2, 3 or 4 weeks. Functional and histopathological studies were done 3 days after the last injection. Dose-response curves for norepinephrine and methacholine were obtained. After 2 weeks of Cd administration significant changes in the secretory response to these sialogogues were observed. The dose-response curves after pretreatment with Cd for 3 weeks were also shifted to the right, but the response showed recovery when compared with that of 2-week treated animals. Parotid amylase concentration was also diminished by Cd. Treated rats had reduced acinar diameters, and an increase in acinar cell nuclei per field in both the submaxillary and parotid glands. Thus sub-chronic administration of ionized Cd produces morphological and functional changes in rat salivary glands. Moreover, the extent of tubular and acinar damage matches the degree of gland dysfunction as judged by the diminution of secretory responses to sialagogues.
研究了亚慢性镉（Cd）给药对颌下腺和腮腺结构以及随后对催涎剂的分泌反应的影响。将雌性Wistar大鼠皮下注射氯化镉（3.0毫克/千克体重），每周4次，持续2、3或4周。在最后一次注射后3天进行功能和组织病理学研究。获得了去甲肾上腺素和乙酰甲胆碱的剂量反应曲线。镉给药2周后，观察到对这些催涎剂的分泌反应有显著变化。镉预处理3周后的剂量反应曲线也向右移动，但与2周治疗的动物相比，反应显示出恢复。腮腺淀粉酶浓度也因镉而降低。处理过的大鼠颌下腺和腮腺的腺泡直径减小，每个视野中的腺泡细胞核数量增加。因此，亚慢性给予离子化镉会使大鼠唾液腺产生形态和功能变化。此外，根据对催涎剂分泌反应的减弱判断，小管和腺泡损伤的程度与腺体功能障碍的程度相匹配。
