六分钟步行试验评估肺癌手术后的呼吸功能：一项队列研究。

The Six-Minute-Walk Test in assessing respiratory function after tumor surgery of the lung: a cohort study.

机构信息

1 Klinik Reinhardshöhe, Klinik für Onkologische Rehabilitation, Quellenstr. 8-12, 34537 Bad Wildungen, Germany ; 2 Division of Pulmonary, Critical Care and Occupational Medicine, Carver College of Medicine, University of Iowa, Iowa City, USA ; 3 Dr. Horst Schmidt Kliniken, Klinik für Thoraxchirurgie, Ludwig Erhard Str. 100, 65199 Wiesbaden, Germany.

出版信息

J Thorac Dis. 2014 May;6(5):421-8. doi: 10.3978/j.issn.2072-1439.2014.03.16.

DOI:10.3978/j.issn.2072-1439.2014.03.16

PMID:24822098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4014995/

Abstract

INTRODUCTION

The Six-Minute-Walk Test (6-MWT) is an established and well-validated diagnostic procedure in cardiovascular and pulmonary diseases. The significance of the 6-MWT in the assessment of the respiratory function in tumor patients after lung surgery is yet unclear.

METHODS

The retrospective study included 227 patients following oncological rehabilitation after lobectomy, pneumonectomy or wedge- and segmental resection due to a malignant tumor disease. Spirometry and 6-MWT were performed at the beginning (T1) and at the end (T2) of oncological rehabilitation and correlated with each other. A subgroup analysis on clinically relevant parameters was conducted as well.

RESULTS

A significant improvement of the walking distance measured in 6-MWT as well as of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were detected within the scope of spirometry (all three P<0.01). This effect was demonstrable in all subgroups, except for patients who underwent pneumonectomy. However, a low correlation of the parameters walking distance and FEV1 was observed at both measurement points T1 (rho value =0.21) and T2 (rho value =0.25).

CONCLUSIONS

Measuring the walking distance in the 6-MWT could be a suitable parameter to assess respiratory function.

摘要

简介

六分钟步行试验（6-MWT）是心血管和肺部疾病中一种既定且经过充分验证的诊断程序。6-MWT 在评估肺癌手术后肿瘤患者的呼吸功能方面的意义尚不清楚。

方法

本回顾性研究纳入了 227 例因恶性肿瘤疾病接受肺叶切除术、全肺切除术或楔形切除术和肺段切除术的肿瘤康复患者。在肿瘤康复的开始（T1）和结束（T2）时进行肺量测定和 6-MWT，并将两者相互关联。还进行了临床相关参数的亚组分析。

结果

在肺量测定范围内，6-MWT 测量的步行距离以及一秒用力呼气容积（FEV1）和用力肺活量（FVC）均显著改善（所有三项均 P<0.01）。除了全肺切除术患者外，在所有亚组中均观察到这种效果。然而，在两个测量点 T1（rho 值=0.21）和 T2（rho 值=0.25），步行距离和 FEV1 参数之间的相关性较低。