Camarri Bernadine, Eastwood Peter R, Cecins Nola M, Thompson Philip J, Jenkins Sue
School of Physiotherapy, Curtin University of Technology, Perth, Western Australia, Australia.
Respir Med. 2006 Apr;100(4):658-65. doi: 10.1016/j.rmed.2005.08.003. Epub 2005 Oct 17.
The six minute walk test (6MWT) is the most commonly used exercise test in pulmonary rehabilitation; however, the paucity of six minute walk distance (6MWD) reference values from population-based samples limits data interpretation in patients. This study was undertaken to determine 6MWD in a population-based sample of healthy subjects and to identify predictors of 6MWD in this group.
Seventy Caucasian subjects (33 males) aged 55-75 years performed three tests using a standardised protocol. 6MWD was defined as the greatest distance achieved from the three tests. Other measurements included height, leg length, weight, forced expiratory volume in 1s (FEV(1)), exhaled carbon monoxide and self-reported physical activity including habitual walking.
The average 6MWD was 659+/-62 m (range 484-820 m). Males walked 59+/-13 m further than females (P<0.001). Height (r=0.54, P<0.01), weight (r=0.25, P<0.05) and FEV(1) (r=0.48, P<0.001) were significantly correlated with 6MWD. Forwards stepwise multiple regression showed height (R(2)=0.294) and FEV(1) (R(2) change=0.045) to be independent predictors of 6MWD (P<0.05), explaining 33.9% of the variance.
6MWD in this healthy population-based sample of males and females exceeds values previously reported. Height and FEV(1) were identified as significant independent predictors of 6MWD in this group.
六分钟步行试验（6MWT）是肺康复中最常用的运动试验；然而，基于人群样本的六分钟步行距离（6MWD）参考值匮乏限制了对患者数据的解读。本研究旨在确定基于人群的健康受试者样本中的6MWD，并识别该组中6MWD的预测因素。
70名年龄在55 - 75岁的白种人受试者（33名男性）按照标准化方案进行了三项测试。6MWD定义为三项测试中达到的最大距离。其他测量指标包括身高、腿长、体重、一秒用力呼气量（FEV(1)）、呼出一氧化碳以及自我报告的身体活动，包括习惯性步行。
平均6MWD为659±62米（范围484 - 820米）。男性比女性多走59±13米（P<0.001）。身高（r = 0.54，P<0.01）、体重（r = 0.25，P<0.05）和FEV(1)（r = 0.48，P<0.001）与6MWD显著相关。向前逐步多元回归显示身高（R(2)=0.294）和FEV(1)（R(2)变化 = 0.045）是6MWD的独立预测因素（P<0.05），解释了33.9%的方差。
在这个基于健康人群的男性和女性样本中，6MWD超过了先前报道的值。身高和FEV(1)被确定为该组中6MWD的重要独立预测因素。
