喉息肉样鳞状细胞癌。ras p21和细胞角蛋白的免疫组织化学研究。

Polypoid squamous cell carcinoma of the larynx. An immunohistochemical study for ras p21 and cytokeratin.

作者信息

Toda S, Yonemitsu N, Miyabara S, Sugihara H, Maehara N

机构信息

Department of Pathology, Saga Medical School, Japan.

出版信息

Pathol Res Pract. 1989 Dec;185(6):860-6. doi: 10.1016/S0344-0338(89)80287-0.

DOI:10.1016/S0344-0338(89)80287-0

PMID:2482483

Abstract

Polypoid squamous cell carcinoma of the larynx consists of two components, namely, squamous cell carcinoma and sarcomatoid spindle cells. To further investigate the histogenesis of the spindle cell component, we studied two cases of polypoid squamous cell carcinoma of the larynx by immunohistochemistry and ultrastructural analysis. Positive staining for ras oncogene p21 and cytokeratin was demonstrated in both squamous cell carcinoma and spindle cell component. Only the latter component was positive for vimentin. Electron microscopic examination showed well-developed desmosomes in spindle cells. These results suggest that the spindle cell component is epithelial in origin and malignantly neoplastic; it originates from mesenchymal metaplasia or squamous cell carcinoma.

摘要

喉息肉样鳞状细胞癌由两个成分组成，即鳞状细胞癌和肉瘤样梭形细胞。为了进一步研究梭形细胞成分的组织发生，我们通过免疫组织化学和超微结构分析对2例喉息肉样鳞状细胞癌进行了研究。在鳞状细胞癌和梭形细胞成分中均显示出原癌基因p21和细胞角蛋白的阳性染色。只有后者成分波形蛋白呈阳性。电镜检查显示梭形细胞中有发育良好的桥粒。这些结果提示梭形细胞成分起源于上皮且为恶性肿瘤；它起源于间充质化生或鳞状细胞癌。