Meijer J W, Ramaekers F C, Manni J J, Slooff J J, Aldeweireldt J, Vooys G P
Department of Pathology, University Hospital of Nijmegen, The Netherlands.
Acta Otolaryngol. 1988 Sep-Oct;106(3-4):306-13. doi: 10.3109/00016488809106441.
In an analysis of intermediate filament protein expression of spindle cell carcinoma, a variant of squamous cell carcinoma, occurring in larynx and tongue, vimentin positivity was found in sarcomatoid areas in 12 of 13 patients. Scattered expression of keratin was observed in sarcomatoid areas in tumours of 10 patients. However, large parts of sarcomatoid areas of such tumours were negative for keratin. Overlying dysplastic epithelium and squamous cell carcinoma components were positive for keratin. In a number of cases there was a strong indication of co-expression of keratin and vimentin in parts of cells that, on histological grounds, belong to sarcomatoid areas or to cells in the interface between carcinoma and spindle cell area. The use of keratin and vimentin type intermediate filament antibodies could be of great help for the correct classification of these tumours.
在一项对发生于喉和舌部的鳞状细胞癌的一种变异型——梭形细胞癌的中间丝蛋白表达的分析中，13例患者中有12例的肉瘤样区域波形蛋白呈阳性。10例患者肿瘤的肉瘤样区域观察到角蛋白呈散在表达。然而，这类肿瘤的肉瘤样区域大部分角蛋白呈阴性。覆盖的发育异常上皮和鳞状细胞癌成分角蛋白呈阳性。在一些病例中，在组织学上属于肉瘤样区域或癌与梭形细胞区域之间界面的细胞部分，有强烈迹象表明角蛋白和波形蛋白共表达。角蛋白和波形蛋白类型的中间丝抗体的应用对这些肿瘤的正确分类可能有很大帮助。
