Magnusson K, Østerås N, Haugen I K, Mowinckel P, Nordsletten L, Natvig B, Hagen K B
Department of Rheumatology, National Resource Centre for Rehabilitation in Rheumatology, Diakonhjemmet Hospital , Norway.
Scand J Rheumatol. 2014;43(5):409-15. doi: 10.3109/03009742.2014.900700. Epub 2014 May 14.
The aim of this population-based case-control study was to investigate whether a high body mass index (BMI) is a risk factor for clinical hand osteoarthritis (OA).
Persons living in Ullensaker municipality in Norway who were aged 20-52 years in 1990 reported height and weight in 1990, 1994, 2004, and 2010 (n = 1276). Cases (clinical hand OA in 2010, n = 59) were compared to controls (participants without self-reported OA or hand pain in 2010, n = 805) with regard to the prospectively measured BMI by means of a generalized estimating equation (GEE) analysis adjusted for age, sex, time, and education.
The mean age of hand OA cases was 64 (SD = 7.5) years in 2010 and 78% were women. There was no association between total average BMI over the entire period and later clinical hand OA (p = 0.320). Cases had a higher mean BMI in 1990 [unstandardized B = 0.93, 95% confidence interval (CI) 0.07-1.79] and in 1994 (B = 0.75, 95% CI 0.22-1.28) but there were no differences between the groups in 2004 or 2010.
The study lend support to the hypothesis that having a higher BMI when young or middle-aged might be associated with later hand OA.
本基于人群的病例对照研究旨在调查高体重指数（BMI）是否为临床手部骨关节炎（OA）的危险因素。
1990年居住在挪威乌伦萨克市、年龄在20 - 52岁之间的人群于1990年、1994年、2004年和2010年报告了身高和体重（n = 1276）。通过广义估计方程（GEE）分析，对病例组（2010年患有临床手部OA，n = 59）和对照组（2010年无自我报告的OA或手部疼痛的参与者，n = 805）的前瞻性测量BMI进行年龄、性别、时间和教育程度的校正。
2010年手部OA病例的平均年龄为64岁（标准差 = 7.5），78%为女性。整个时期的总平均BMI与后期临床手部OA之间无关联（p = 0.320）。病例组在1990年的平均BMI较高[未标准化B = 0.93，95%置信区间（CI）0.07 - 1.79]，在1994年也较高（B = 0.75，95%CI 0.22 - 1.28），但在2004年或2010年两组之间无差异。
该研究支持了年轻时或中年时BMI较高可能与后期手部OA相关的假说。
