Magnusson K, Slatkowsky-Christensen B, van der Heijde D, Kvien T K, Hagen K B, Haugen I K
National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Hospital , Oslo , Norway.
Scand J Rheumatol. 2015;44(4):331-6. doi: 10.3109/03009742.2014.994560. Epub 2015 Mar 6.
Few longitudinal studies have studied the association between body mass index (BMI) and hand osteoarthritis (OA). We aimed to explore the association between BMI and progressive hand OA in a longitudinal study of the Oslo hand OA cohort.
Participants with existing hand OA had hand radiographs and BMI data taken at baseline and 7-year follow-up (n = 103). The radiographs were read according to the Kellgren-Lawrence (KL) scale. First, we examined the association between baseline BMI and incident OA (KL grade ≥ 2) in joints without OA at baseline (adjusted for age and sex) using generalized estimating equation (GEE) analyses. Second, we examined whether changes in BMI from baseline to follow-up were associated with increasing KL sum score from baseline to follow-up using linear regression. We repeated the analyses using changes in number of joints with symptomatic OA and patient-reported pain and physical function as the outcome.
The mean (SD) age at baseline was 61.6 (5.6) years and 91 (94%) of the cohort were women. The mean (SD) BMI was 25.7 (4.0) kg/m(2) at baseline and the mean (SD) BMI change was 1.1 (2.0) kg/m(2). There was no relationship between baseline BMI and development of more joints with OA during follow-up. Similarly, there was no association between change in BMI and hand OA progression, increasing hand pain or disability.
In the Oslo hand OA cohort, higher BMI was not related to hand OA progression.
很少有纵向研究探讨体重指数（BMI）与手部骨关节炎（OA）之间的关联。我们旨在通过对奥斯陆手部骨关节炎队列的纵向研究，探究BMI与进展性手部OA之间的关联。
患有手部OA的参与者在基线期和7年随访期拍摄手部X光片并测量BMI数据（n = 103）。X光片依据凯尔格伦-劳伦斯（KL）分级标准进行判读。首先，我们使用广义估计方程（GEE）分析，在调整年龄和性别后，研究基线BMI与基线时无OA关节的新发OA（KL分级≥2）之间的关联。其次，我们使用线性回归分析，研究从基线到随访期间BMI的变化是否与从基线到随访期间KL总分的增加相关。我们以有症状OA的关节数量变化以及患者报告的疼痛和身体功能作为结局指标，重复上述分析。
基线时的平均（标准差）年龄为61.6（5.6）岁，队列中的91名（94%）为女性。基线时的平均（标准差）BMI为25.7（4.0）kg/m²，BMI的平均（标准差）变化为1.1（2.0）kg/m²。随访期间，基线BMI与更多关节发生OA的发展之间没有关系。同样，BMI的变化与手部OA进展、手部疼痛加剧或残疾之间也没有关联。
在奥斯陆手部OA队列中，较高的BMI与手部OA进展无关。
