Kheifets Julia, Rozhavsky Boris, Girsh Solomonovich Zehava, Marianna Rodman, Soroksky Arie
Intensive Care Unit, Wolfson Medical Center, Holon, Israel.
Case Rep Crit Care. 2012;2012:782507. doi: 10.1155/2012/782507. Epub 2012 Oct 1.
Lagocephalus sceleratus, or better known as the pufferfish, or fugu, is widespread in Asia and Indo-Pacific regions. It is a poisonous fish containing tetrodotoxin (TTX) which is a potent neurotoxin. In the Far East, fugu is considered a delicate dish, especially in Japan where it is prepared by experts. Nevertheless, poisoning from Lagocephalus sceleratus is not a rare event. Recent data from Japan indicate an incidence of 45 patients per year and a mortality rate of 11%. Mediterranean sea is not the natural habitat of Lagocephalus sceleratus. However, by now multiple reports have established a firm presence of Lagocephalus sceleratus in Mediterranean region as well. This phenomenon is explained by migration of pufferfish across the Suez Channel (lessepsian migration) (Eisenman et al., 2008, Bentur et al., 2008). With lessepsian migration came the first reports of TTX poisoning in the Mediterranean region. We report a patient with a particularly severe and life-threatening TTX poisoning caused by consumption of Lagocephalus sceleratus and treated by cholinesterase inhibitor to a complete and uneventful recovery.
暗鳍兔头鲀，更广为人知的名称是河豚或河鲀，广泛分布于亚洲和印度-太平洋地区。它是一种含有河豚毒素（TTX）的有毒鱼类，河豚毒素是一种强效神经毒素。在远东地区，河豚被视为一道精致菜肴，尤其是在日本，由专业厨师烹制。然而，因暗鳍兔头鲀中毒并非罕见事件。日本最近的数据显示，每年有45例患者，死亡率为11%。地中海并非暗鳍兔头鲀的自然栖息地。然而，到目前为止，多份报告也证实了地中海地区也有暗鳍兔头鲀的存在。这种现象可以通过河豚穿越苏伊士运河的迁移（莱塞普斯迁移）来解释（艾森曼等人，2008年；本图尔等人，2008年）。随着莱塞普斯迁移，地中海地区首次出现了河豚毒素中毒的报告。我们报告了一名因食用暗鳍兔头鲀而导致特别严重且危及生命的河豚毒素中毒患者，经胆碱酯酶抑制剂治疗后完全康复且未出现并发症。
