Patel Neepa, Hanfelt John, Marsh Laura, Jankovic Joseph
Department of Neurology and Neurotherapeutics, Center for Movement Disorders, University of Texas Southwestern, Dallas, Texas, USA.
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA.
J Neurol Neurosurg Psychiatry. 2014 Aug;85(8):882-4. doi: 10.1136/jnnp-2013-307316. Epub 2014 May 14.
There is limited information on the phenomenology, clinical characteristics and pathophysiology of alleviating manoeuvres (AM), also called 'sensory tricks' in cervical dystonia (CD).
Individual data, collected from 10 sites participating in the Dystonia Coalition (http://clinicaltrials.gov/show/NCT01373424), included description of localisation and phenomenology of AM collected by systematic review of standardised video examinations. Analyses correlated demographic, neurologic, and psychiatric features of CD patients with or without effective AM.
Of 154 people studied, 138 (89.6%) used AM, of which 60 (43.4%) reported partial improvement, 55 (39.8%) marked improvement, and 4 (0.03%) no effect on dystonic posture. Light touch, usually to the lower face or neck, was used by >90%. The presence or location of AM did not correlate with the severity of the dystonia.
In this large and comprehensive study of CD, we found no clinical predictors of effective AM. Further studies of sensorimotor integration in dystonia are needed to better understand the pathophysiology of AM.
关于缓解动作(AM)的现象学、临床特征及病理生理学的信息有限,缓解动作在颈部肌张力障碍(CD)中也被称为“感觉技巧”。
在154名研究对象中,138名(89.6%)使用了缓解动作,其中60名(43.4%)报告肌张力障碍姿势有部分改善,55名(39.8%)有显著改善,4名(0.03%)无改善。超过90%的人使用轻触,通常是触摸下脸部或颈部。缓解动作的存在或位置与肌张力障碍的严重程度无关。
在这项关于颈部肌张力障碍的大型综合性研究中,我们未发现有效缓解动作的临床预测因素。需要对肌张力障碍中的感觉运动整合进行进一步研究,以更好地理解缓解动作的病理生理学机制。