Johnson James G, Blair Robert, Brandão João, Tully Thomas N, Gaunt Stephen D
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
Vet Clin Pathol. 2014 Jun;43(2):281-4. doi: 10.1111/vcp.12146. Epub 2014 May 14.
A 2.5-year-old intact male Roborovski hamster (Phodopus roborovskii) was presented with a large subcutaneous mass overlying the abdomen, affecting the animal's ambulation and access to different compartments of the cage through narrow tubing. Ultrasound examination delineated a well-circumscribed mass in the subcutis of the caudoventral abdominal region. The mass was surgically excised and on cytologic examination showed, in a background of blood, a small population of individually arranged oval to spindle-shaped cells that exhibited a moderate degree of anisokaryosis, coarsely stippled chromatin, one or more prominent nucleoli, and lightly basophilic well-defined cytoplasmic processes. Histologically, the mass was composed of interlacing streams and bundles of pleomorphic spindle cells (ganglion-like cells) with variable amounts of collagenous stroma. The neoplastic cells exhibited moderate features of malignancy. These cells stained intensely with vimentin, but not with any other markers, including antibodies to cytokeratin AE1/AE3, S100 protein, desmin, smooth muscle actin, synaptophysin, neurofilament, and androgen receptor. Based on histologic features, the mass was diagnosed as an atypical fibrosarcoma. This is the first report of an atypical fibrosarcoma in a Roborovski hamster and one of few reports of atypical fibrosarcoma in domesticated hamsters overall.
一只2.5岁未绝育的雄性罗伯罗夫斯基仓鼠（Phodopus roborovskii）被发现腹部有一个大的皮下肿块，影响了该动物的行走，使其无法通过狭窄的管道进入笼子的不同隔层。超声检查显示在腹尾侧皮下有一个边界清晰的肿块。该肿块被手术切除，细胞学检查显示，在血液背景中，有一小群单个排列的椭圆形至梭形细胞，这些细胞表现出中度核异形性、粗颗粒状染色质、一个或多个明显的核仁以及轻度嗜碱性、边界清晰的细胞质突起。组织学上，肿块由交织的束状和束状多形性梭形细胞（神经节样细胞）组成，伴有不同数量的胶原性间质。肿瘤细胞表现出中度恶性特征。这些细胞对波形蛋白染色强烈，但对任何其他标志物均不染色，包括细胞角蛋白AE1/AE3、S100蛋白、结蛋白、平滑肌肌动蛋白、突触素、神经丝和雄激素受体的抗体。根据组织学特征，该肿块被诊断为非典型纤维肉瘤。这是罗伯罗夫斯基仓鼠中非典型纤维肉瘤的首例报告，也是家养仓鼠中总体上为数不多的非典型纤维肉瘤报告之一。
