Kashida Yoko, Ishikawa Kazumi, Arai Katsuhiko, Mitsumori Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan.
Vet Pathol. 2003 Sep;40(5):548-55. doi: 10.1354/vp.40-5-548.
Characteristic ganglion-like cell proliferation observed in the skin of Djungarian hamsters was investigated using 24 male and 24 female hamsters, 1-6 months of age, to examine the anatomic location of these ganglion-like cells and their morphologic features. One abdominal skin tumor composed of these cells and resembling proliferative fasciitis in humans was also examined. Skin ganglion-like cells were rarely observed in young animals but increased in number and extent with age, especially in males. These cells were frequently seen in the ventral and medial regions of the trunk and legs rather than in the dorsal and lateral regions. Light microscopic examination of these ganglion-like cells revealed abundant vesicular basophilic cytoplasm with delicate intracytoplasmic silver stain-positive fibrils. Ultrastructurally, these cells contained abundant rough endoplasmic reticulum and Golgi complexes with dilated cisternae; intracellular collagen fibrils were present within these cisternae. Heat shock protein 47, beta-tubulin, and androgen receptor were expressed in these cells. The morphologic features of cells of one tumor resembling human proliferative fasciitis were identical to those observed in ganglion-like cells. The results of the present study suggest that these ganglion-like cells are derived from intrinsic undifferentiated mesenchymal cells in the dermis or subcutaneous adipose tissue and that any tumor-like lesion they form should be regarded as an abnormal proliferative lesion of skin ganglion-like cells rather than as proliferative fasciitis or fibroma.
利用24只1至6月龄的雄性和24只雌性侏儒仓鼠，对在其皮肤中观察到的特征性神经节样细胞增殖进行了研究，以检查这些神经节样细胞的解剖位置及其形态特征。还检查了一个由这些细胞组成且类似于人类增殖性筋膜炎的腹部皮肤肿瘤。神经节样细胞在幼龄动物中很少见，但随着年龄增长数量和范围增加，尤其是在雄性动物中。这些细胞常见于躯干和腿部的腹侧和内侧区域，而非背侧和外侧区域。对这些神经节样细胞进行光镜检查发现，其具有丰富的泡状嗜碱性细胞质，胞质内有纤细的银染阳性纤维。超微结构上，这些细胞含有丰富的粗面内质网和高尔基复合体，其潴泡扩张；潴泡内存在细胞内胶原纤维。热休克蛋白47、β微管蛋白和雄激素受体在这些细胞中表达。一个类似于人类增殖性筋膜炎的肿瘤细胞的形态特征与在神经节样细胞中观察到的相同。本研究结果表明，这些神经节样细胞源自真皮或皮下脂肪组织中的固有未分化间充质细胞，它们形成的任何肿瘤样病变都应被视为皮肤神经节样细胞的异常增殖性病变，而非增殖性筋膜炎或纤维瘤。
