胃癌的多模式治疗
Multimodal treatment of gastric cancer.
作者信息
Proserpio Ilaria, Rausei Stefano, Barzaghi Sabrina, Frattini Francesco, Galli Federica, Iovino Domenico, Rovera Francesca, Boni Luigi, Dionigi Gianlorenzo, Pinotti Graziella
机构信息
Ilaria Proserpio, Sabrina Barzaghi, Graziella Pinotti, Department of Oncology, Ospedale di Circolo and University of Insubria, 21100 Varese, Italy.
出版信息
World J Gastrointest Surg. 2014 Apr 27;6(4):55-8. doi: 10.4240/wjgs.v6.i4.55.
Abstract
Gastric cancer is the second leading cause of death from malignant disease worldwide. Although complete surgical resection remains the only curative modality for early stage gastric cancer, surgery alone only provides long-term survival in 20% of patients with advanced-stage disease. To improve current results, it is necessary to consider multimodality treatment, including chemotherapy, radiotherapy and surgery. Recent clinical trials have shown survival benefit of combining different neoadjuvant or adjuvant protocols compared with surgery with curative intent. Furthermore, the implementation of chemotherapy with novel targeted agents could play an important role in the multimodal management of advanced gastric cancer. In this paper, we focus on a multidisciplinary approach in the treatment of gastric cancer and discuss future strategies to improve the outcome for these patients.
摘要
胃癌是全球恶性疾病致死的第二大主要原因。尽管完整的手术切除仍然是早期胃癌唯一的治愈方式，但仅手术治疗只能使20%的晚期胃癌患者获得长期生存。为改善当前治疗效果，有必要考虑多模式治疗，包括化疗、放疗和手术。最近的临床试验表明，与根治性手术相比，联合不同的新辅助或辅助方案可带来生存获益。此外，新型靶向药物化疗在晚期胃癌的多模式治疗中可能发挥重要作用。在本文中，我们聚焦于胃癌治疗的多学科方法，并探讨改善这些患者治疗结局的未来策略。
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