Herzog Torsten, Belyaev Orlin, Hessam Schapoor, Uhl Waldemar, Chromik Ansgar M
Department of Surgery, St. Josef Hospital Bochum, Ruhr University Bochum, Germany.
J Invest Surg. 2014 Oct;27(5):273-81. doi: 10.3109/08941939.2014.916368. Epub 2014 May 15.
After pancreatectomy, an isolated bile leak from the hepaticojejunostomy is a severe surgical complication that is underrepresented both, in the literature and in the awareness of pancreatic surgeons. The goal of this study was to analyze the incidence and outcome of isolated bile leaks after pancreatectomy.
A retrospective study of patients who underwent duodenopancreatectomy or total pancreatectomy at a single-center institution was performed, which analyzed incidence and course of patients with postoperative bile leaks from the hepaticojejunostomy.
During a period of 42 months, 209 patients underwent pancreatic head resection or total pancreatectomy. Bile leaks occurred in 4% (8/209) and were more common in patients with distal bile duct cancer. Bile leaks led to longer hospital stay and were associated with abscess formation and other infectious complications. Unlike expected, most postoperative bile leaks occurred in the late postoperative period. Three patients required relaparotomy for biliary peritonitis or delayed visceral hemorrhage, while the other five patients underwent conservative management, including CT drainage and antibiotic therapy. One patient with a postoperative bile leak died due to delayed visceral hemorrhage.
In contrast to recently published data, isolated postoperative bile leaks after pancreatectomy often occur in the late postoperative period and more frequently require a relaparotomy than the literature suggests. The presented study results may sensitize surgeons for this often disregarded topic and activate the discussion on treatment options.
胰腺切除术后,肝空肠吻合口出现孤立性胆漏是一种严重的手术并发症,在文献报道及胰腺外科医生的认知中都未得到充分体现。本研究的目的是分析胰腺切除术后孤立性胆漏的发生率及预后情况。
对在单中心机构接受十二指肠胰腺切除术或全胰腺切除术的患者进行回顾性研究,分析肝空肠吻合口术后胆漏患者的发生率及病程。
在42个月的时间里,209例患者接受了胰头切除术或全胰腺切除术。胆漏发生率为4%(8/209),在远端胆管癌患者中更为常见。胆漏导致住院时间延长,并与脓肿形成及其他感染性并发症相关。与预期不同的是,大多数术后胆漏发生在术后晚期。3例患者因胆汁性腹膜炎或延迟性内脏出血需要再次剖腹手术,而其他5例患者接受了保守治疗,包括CT引导下引流和抗生素治疗。1例术后胆漏患者因延迟性内脏出血死亡。
与最近发表的数据相反,胰腺切除术后孤立性术后胆漏常发生在术后晚期,且比文献报道的更频繁地需要再次剖腹手术。本研究结果可能会提高外科医生对这个常被忽视话题的认识,并引发关于治疗选择的讨论。