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胰腺切除术后孤立性胆瘘的管理

Management of isolated bile leaks after pancreatic resections.

作者信息

Herzog Torsten, Belyaev Orlin, Hessam Schapoor, Uhl Waldemar, Chromik Ansgar M

机构信息

Department of Surgery, St. Josef Hospital Bochum, Ruhr University Bochum, Germany.

出版信息

J Invest Surg. 2014 Oct;27(5):273-81. doi: 10.3109/08941939.2014.916368. Epub 2014 May 15.

DOI:10.3109/08941939.2014.916368
PMID:24830477
Abstract

INTRODUCTION

After pancreatectomy, an isolated bile leak from the hepaticojejunostomy is a severe surgical complication that is underrepresented both, in the literature and in the awareness of pancreatic surgeons. The goal of this study was to analyze the incidence and outcome of isolated bile leaks after pancreatectomy.

MATERIAL AND METHODS

A retrospective study of patients who underwent duodenopancreatectomy or total pancreatectomy at a single-center institution was performed, which analyzed incidence and course of patients with postoperative bile leaks from the hepaticojejunostomy.

RESULTS

During a period of 42 months, 209 patients underwent pancreatic head resection or total pancreatectomy. Bile leaks occurred in 4% (8/209) and were more common in patients with distal bile duct cancer. Bile leaks led to longer hospital stay and were associated with abscess formation and other infectious complications. Unlike expected, most postoperative bile leaks occurred in the late postoperative period. Three patients required relaparotomy for biliary peritonitis or delayed visceral hemorrhage, while the other five patients underwent conservative management, including CT drainage and antibiotic therapy. One patient with a postoperative bile leak died due to delayed visceral hemorrhage.

CONCLUSION

In contrast to recently published data, isolated postoperative bile leaks after pancreatectomy often occur in the late postoperative period and more frequently require a relaparotomy than the literature suggests. The presented study results may sensitize surgeons for this often disregarded topic and activate the discussion on treatment options.

摘要

引言

胰腺切除术后,肝空肠吻合口出现孤立性胆漏是一种严重的手术并发症,在文献报道及胰腺外科医生的认知中都未得到充分体现。本研究的目的是分析胰腺切除术后孤立性胆漏的发生率及预后情况。

材料与方法

对在单中心机构接受十二指肠胰腺切除术或全胰腺切除术的患者进行回顾性研究,分析肝空肠吻合口术后胆漏患者的发生率及病程。

结果

在42个月的时间里,209例患者接受了胰头切除术或全胰腺切除术。胆漏发生率为4%(8/209),在远端胆管癌患者中更为常见。胆漏导致住院时间延长,并与脓肿形成及其他感染性并发症相关。与预期不同的是,大多数术后胆漏发生在术后晚期。3例患者因胆汁性腹膜炎或延迟性内脏出血需要再次剖腹手术,而其他5例患者接受了保守治疗,包括CT引导下引流和抗生素治疗。1例术后胆漏患者因延迟性内脏出血死亡。

结论

与最近发表的数据相反,胰腺切除术后孤立性术后胆漏常发生在术后晚期,且比文献报道的更频繁地需要再次剖腹手术。本研究结果可能会提高外科医生对这个常被忽视话题的认识,并引发关于治疗选择的讨论。

相似文献

1
Management of isolated bile leaks after pancreatic resections.胰腺切除术后孤立性胆瘘的管理
J Invest Surg. 2014 Oct;27(5):273-81. doi: 10.3109/08941939.2014.916368. Epub 2014 May 15.
2
The difficult hepaticojejunostomy after pancreatic head resection: reconstruction with a T tube.胰头切除术后困难的胆肠吻合术:T 管重建。
Am J Surg. 2013 Oct;206(4):578-85. doi: 10.1016/j.amjsurg.2013.01.044. Epub 2013 Jul 30.
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[Hepaticojejunostomy after pancreatic head resection - technical aspects for reconstruction of small and fragile bile ducts with T-tube drainage].胰头切除术后肝空肠吻合术——采用T管引流重建细小脆弱胆管的技术要点
Zentralbl Chir. 2012 Dec;137(6):559-64. doi: 10.1055/s-0032-1328008. Epub 2012 Dec 21.
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Hepatogastroenterology. 2003 Jan-Feb;50(49):254-7.
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Defining treatment and outcomes of hepaticojejunostomy failure following pancreaticoduodenectomy.定义胰十二指肠切除术后胆肠吻合口失败的治疗和结果。
J Gastrointest Surg. 2013 Mar;17(3):451-60. doi: 10.1007/s11605-012-2118-9. Epub 2013 Jan 5.
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[Leakage after biliary and pancreatic surgery].[胆胰手术后的渗漏]
Chirurg. 2004 Nov;75(11):1079-87. doi: 10.1007/s00104-004-0946-1.
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To Stent or Not To Stent Hepaticojejunostomy--Analysis of Risk Factors for Postoperative Bile Leaks and Surgical Complication.肝空肠吻合术是否置入支架——术后胆漏及手术并发症的危险因素分析
Hepatogastroenterology. 2014 Jun;61(132):920-6.
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Endotherapy for bile leaks from isolated ducts after hepatic resection: A long awaited challenge.肝切除术后孤立胆管胆漏的内镜治疗:期待已久的挑战。
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Pancreatic anastomotic leak after pancreaticoduodenectomy: incidence, significance, and management.胰十二指肠切除术后胰肠吻合口漏:发生率、意义及处理
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Safety and efficacy of the percutaneous treatment of bile leaks in hepaticojejunostomy or split-liver transplantation without dilatation of the biliary tree.肝空肠吻合术或劈离式肝移植中不经胆道扩张经皮治疗胆漏的安全性和有效性
Liver Transpl. 2008 May;14(5):611-5. doi: 10.1002/lt.21416.

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[Biliary fistulas and biliary congestion after hepatopancreaticobiliary surgery].[肝胰胆手术后的胆瘘和胆汁淤积]
Chirurg. 2015 Jun;86(6):547-51. doi: 10.1007/s00104-015-0005-0.