Nowakowska-Kotas Marta, Kędzia Alicja, Dudek Krzysztof
Department of Neurology, Wrocław Medical University, ul. Borowska 213, 50-556, Wrocław, Poland,
Cerebellum. 2014 Oct;13(5):541-8. doi: 10.1007/s12311-014-0566-3.
In the fetal period, development of cerebellar lobes may proceed dissimilarly due to possible differentiated origins of the cells and diversified times of their migration to certain cerebellum regions. This can cause various growth trajectories for the external surfaces of cerebellar lobes. The goal of the study was to describe the development of the external surface of cerebellum lobes and fissures delineating them in the fetal period. The material consisted of 101 fetuses (48 males and 53 females)-crown rump length 89-229 mm corresponding to 15-28 weeks of fetal life. The methods were based on anthropometric measurements and preparation techniques combined with elicited image computer analysis. At the largest values of the cerebellum posterior lobe surface, the most dynamic growth rate was observed in the case of the anterior lobe. Among the cerebellar lobes, proportional change was observed as well as a gradual increase in anterior lobe surface area and a simultaneous decrease in the surface area of the flocculonodular lobe part of the cerebellum total external surface. This paper presents the different growth trajectories of cerebellar lobes and demonstrates the importance of the primary fissure as a delineating mark for two regions with different dynamics of development.
在胎儿期，小脑叶的发育可能会因细胞起源的差异以及它们迁移到特定小脑区域的时间不同而有所不同。这可能导致小脑叶外表面出现各种生长轨迹。本研究的目的是描述胎儿期小脑叶外表面及其裂隙的发育情况。研究材料包括101例胎儿（48例男性和53例女性），顶臀长89 - 229毫米，相当于胎儿15 - 28周的孕期。研究方法基于人体测量学测量和制备技术，并结合图像计算机分析。在小脑后叶表面面积最大时，前叶的生长速度最为活跃。在各小脑叶中，观察到了比例变化，前叶表面积逐渐增加，而小脑总外表面的绒球小结叶部分表面积则同时减少。本文展示了小脑叶不同的生长轨迹，并证明了初级裂作为两个发育动态不同区域的分界标志的重要性。
