Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, the National Institutes of Health, Bethesda, MD 20892, USA.
Biology (Basel). 2012 Jul 23;1(2):165-74. doi: 10.3390/biology1020165.
Post-transcriptional regulation of HIV-1 gene expression is largely governed by the activities of the viral Rev protein. In this minireview, the multiple post-transcriptional activities of Rev in the export of partially spliced and unspliced HIV-1 RNAs from the nucleus to the cytoplasm, in the translation of HIV-1 transcripts, and in the packaging of viral genomic RNAs are reviewed in brief.
HIV-1 基因表达的转录后调控主要受病毒 Rev 蛋白的活性控制。在这篇简评中，简要回顾了 Rev 在 HIV-1 RNA 从核内输出到细胞质、HIV-1 转录本翻译以及病毒基因组 RNA 包装过程中的多种转录后活性。
