Institut National de la Santé et de la Recherche Médicale (INSERM), Créteil, France,
Plant Cell Rep. 2014 Aug;33(8):1217-25. doi: 10.1007/s00299-014-1629-0. Epub 2014 May 15.
Plants have evolved with complex signaling circuits that operate under multiple conditions and govern numerous cellular functions. Stress signaling in plant cells is a sophisticated network composed of interacting proteins organized into tiered cascades where the function of a molecule is dependent on the interaction and the activation of another. In a linear scheme, the receptors of cell surface sense the stimuli and convey stress signals through specific pathways and downstream phosphorylation events controlled by mitogen-activated protein (MAP) kinases and second messengers, leading to appropriate adaptive responses. The specificity of the pathway is guided by scaffolding proteins and docking domains inside the interacting partners with distinctive structures and functions. The flexibility and the fine-tuned organization of the signaling molecules drive the activated MAP kinases into the appropriate location and connection to control and integrate the information flow. Here, we overview recent findings of the involvement of MAP kinases in major abiotic stresses (drought, cold and temperature fluctuations) and we shed light on the complexity and the specificity of MAP kinase signaling modules.
植物已经进化出复杂的信号传导回路，这些回路可以在多种条件下运作，并控制众多细胞功能。植物细胞中的应激信号是一个复杂的网络，由相互作用的蛋白质组成，这些蛋白质组织成层次级联，其中一个分子的功能取决于另一个分子的相互作用和激活。在线性方案中，细胞膜受体感知刺激，并通过特定途径和由丝裂原激活蛋白 (MAP) 激酶和第二信使控制的下游磷酸化事件传递应激信号，导致适当的适应性反应。途径的特异性由支架蛋白和对接域引导，这些支架蛋白和对接域位于具有独特结构和功能的相互作用伙伴内部。信号分子的灵活性和精细组织驱动激活的 MAP 激酶进入适当的位置和连接，以控制和整合信息流。在这里，我们概述了 MAP 激酶在主要非生物胁迫（干旱、寒冷和温度波动）中的参与的最新发现，并阐明了 MAP 激酶信号模块的复杂性和特异性。
