减毒麻疹病毒（MV）的抗肿瘤病毒疗法。
Antitumor Virotherapy by Attenuated Measles Virus (MV).
机构信息
INSERM, UMR892, Nantes, F-44000, France.
CNRS, URA3015, Institut Pasteur, Unité de Génomique Virale et Vaccination, Paris, 75015, France.
出版信息
Biology (Basel). 2013 Mar 28;2(2):587-602. doi: 10.3390/biology2020587.
Abstract
Antitumor virotherapy consists of the use of replication-competent viruses to infect and kill tumor cells preferentially, without damaging healthy cells. Vaccine-attenuated strains of measles virus (MV) are good candidates for this approach. Attenuated MV uses the CD46 molecule as a major entry receptor into cells. This molecule negatively regulates the complement system and is frequently overexpressed by cancer cells to escape lysis by the complement system. MV exhibits oncolytic properties in many cancer types in vitro, and in mouse models. Phase I clinical trials using MV are currently underway. Here, we review the state of this therapeutic approach, with a focus on the effects of MV on the antitumor immune response.
摘要
肿瘤溶瘤病毒治疗是指使用复制型病毒选择性感染和杀伤肿瘤细胞，而不损伤健康细胞。减毒麻疹病毒（MV）是该方法的良好候选物。减毒 MV 利用 CD46 分子作为细胞进入的主要受体。该分子负性调节补体系统，并且在癌细胞中经常过表达以逃避补体系统的裂解。MV 在体外和小鼠模型中对多种癌症类型具有溶瘤特性。目前正在进行使用 MV 的 I 期临床试验。在这里，我们综述了该治疗方法的现状，重点介绍了 MV 对肿瘤免疫反应的影响。
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