Helal Soheir F, Gomaa Howayda E, Thabet Eman H, Younan Mariam A, Helmy Neveen A
Virology and Clinical Pathology Department, Cairo University, Egypt.
Clinical and Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Clin Med Insights Gastroenterol. 2014 Apr 1;7:19-24. doi: 10.4137/CGast.S13658. eCollection 2014.
Immunoregulatory cytokines may influence the hepatitis C virus (HCV) infection outcome. This study aimed to determine the genotypic and allelic frequencies of the interleukin (IL)-10 (-1082) G/A polymorphism, and its association with chronicity or resolution of HCV genotype 4 infection in Egypt. The frequencies of different dimorphic polymorphisms based on single nucleotide substitution in chronic HCV patients (50) and resolved HCV patients (50) were: IL-10 (-1082) G/G 22 (44%) and 18 (36%), G/A 19 (38%) and 24 (48%), and A/A 9 (18%), and 8 (16%), respectively. In the sustained virologic response (SVR) (36) and spontaneously resolved subjects (14) groups, the frequencies were: IL-10 (-1082) G/G 11 (30.6%) and 7 (50%) G/A 18 (50%) and 6 (42.9%), A/A 7 (19.4%) and 1 (7.1%), respectively. An association between male gender and chronic hepatitis C outcome (P value 0.041) was found. However, no significant gender difference was found when we compared females versus males with elevated alanine transaminase (ALT) levels in the chronic HCV patient group (P value = 1).
No significant difference in the frequency of IL-10 single nucleotide polymorphism (SNP) at position 1082 was found between chronic and resolved HCV subjects.
免疫调节细胞因子可能影响丙型肝炎病毒（HCV）感染的结果。本研究旨在确定白细胞介素（IL）-10（-1082）G/A多态性的基因型和等位基因频率，及其与埃及HCV 4型感染的慢性化或痊愈的关联。慢性HCV患者（50例）和痊愈HCV患者（50例）中基于单核苷酸替换的不同双态多态性频率分别为：IL-10（-1082）G/G 22例（44%）和18例（36%），G/A 19例（38%）和24例（48%），以及A/A 9例（18%）和8例（16%）。在持续病毒学应答（SVR）组（36例）和自发痊愈组（14例）中，频率分别为：IL-10（-1082）G/G 11例（30.6%）和7例（50%），G/A 18例（50%）和6例（42.9%），A/A 7例（19.4%）和1例（7.1%）。发现男性性别与慢性丙型肝炎结局之间存在关联（P值0.041）。然而，在慢性HCV患者组中比较丙氨酸转氨酶（ALT）水平升高的女性和男性时，未发现显著的性别差异（P值 = 1）。
慢性和痊愈的HCV受试者之间在1082位的IL-10单核苷酸多态性（SNP）频率上未发现显著差异。
