Huzhou Teachers College School of Medicine, Huzhou, Zhejiang 313000, China.
Chin Med J (Engl). 2010 May 20;123(10):1338-44.
Interleukin 10 (IL-10) is an important cytokine with anti-inflammatory, anti-immune and anti-fibrotic functions. This study aimed at evaluating the relationship between allele polymorphisms in the IL-10 promoter region and hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.
The odds ratios (ORs) of IL-10 allele distributions in patients with HBV or HCV infection were analyzed against healthy controls. All the relevant studies in PubMed were identified, and poor qualified studies were excluded. The meta-analysis software REVMAN 4.2 was applied for investigating heterogeneity among individual studies and summarizing all the studies. The publication bias was also evaluated.
This study demonstrated a significant association between the IL-10-592 A/C polymorphism and HBV infection in the Asian population under the overall effect size of allele A versus C. In our subgroup meta-analysis, we found a significant association of IL-10-592 A/C polymorphism to HCV infection susceptibility in Asian populations, although sensitivity analysis showed that the combined result was not associated with the worldwide population. Other IL-10 allele polymorphisms were not associated with HBV or HCV infection.
IL-10-592 A/C allele might be a risk factor for HBV or HCV in Asians but not in Europeans.
白细胞介素 10（IL-10）是一种具有抗炎、免疫抑制和抗纤维化功能的重要细胞因子。本研究旨在评估白细胞介素 10 启动子区域等位基因多态性与乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）感染之间的关系。
分析 HBV 或 HCV 感染患者与健康对照者之间白细胞介素 10 等位基因分布的优势比（OR）。在 PubMed 中确定了所有相关研究，并排除了不合格的研究。使用 meta 分析软件 REVMAN 4.2 评估个体研究之间的异质性并总结所有研究。还评估了发表偏倚。
本研究表明，在总体等位基因 A 与 C 的效应大小下，IL-10-592 A/C 多态性与亚洲人群的 HBV 感染之间存在显著关联。在我们的亚组 meta 分析中，我们发现 IL-10-592 A/C 多态性与亚洲人群 HCV 感染易感性之间存在显著关联，尽管敏感性分析表明，综合结果与全球人群无关。其他白细胞介素 10 等位基因多态性与 HBV 或 HCV 感染无关。
IL-10-592 A/C 等位基因可能是亚洲人群 HBV 或 HCV 的危险因素，但不是欧洲人群的危险因素。
