Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland.
Cytokine Growth Factor Rev. 2012 Feb-Apr;23(1-2):47-59. doi: 10.1016/j.cytogfr.2012.01.005. Epub 2012 Mar 4.
The clinical outcome of hepatitis C virus (HCV) infection varies between individuals - from spontaneous viral clearance and persistence without complication, to chronic hepatitis, cirrhosis and hepatocellular carcinoma. Also patterns of response to interferon-based anti-HCV therapy are different from person to person. This diversity may be affected by host genetic factors, including alterations in genes encoding cytokines. Interleukin-10, as an anti-inflammatory cytokine and immune response modulator, may influence on HCV infection susceptibility as well as spontaneous and treatment-induced HCV eradication. Moreover, it is stated that IL-10 has antifibrotic properties and play a role in progression of liver disease. This review summarized studies on interleukin-10 gene polymorphisms (mainly promoter SNPs at positions -1082(G/A), -819(C/T) and -592(C/A)), which may determine IL-10 production, regarding susceptibility to HCV infection, course of HCV-related liver disease (fibrosis, cirrhosis, hepatocellular carcinoma, ALT abnormalities), spontaneous viral elimination as well as hepatitis C treatment outcomes. Analysis of hereby summarized studies shows that it is difficult to unambiguously determine the importance of IL-10 polymorphism as a predictor of clinical outcome of hepatitis C and response to anti-HCV therapy before its beginning. Thus, future larger studies need to address these issues. Continuation of studies on interleukin-10 polymorphisms as well as identification of other candidate predictive markers in HCV infection has important practical implications and there is a chance that may contribute to reduce the scale of hepatitis C problem.
丙型肝炎病毒 (HCV) 感染的临床结果因人而异——从自发性病毒清除和无并发症持续存在，到慢性肝炎、肝硬化和肝细胞癌。此外，对基于干扰素的抗 HCV 治疗的反应模式也因人而异。这种多样性可能受宿主遗传因素的影响，包括细胞因子编码基因的改变。白细胞介素 10 作为一种抗炎细胞因子和免疫反应调节剂，可能影响 HCV 感染易感性以及自发性和治疗诱导的 HCV 清除。此外，有人指出，IL-10 具有抗纤维化特性，并在肝病进展中发挥作用。本综述总结了关于白细胞介素 10 基因多态性（主要是位于 -1082(G/A)、-819(C/T) 和 -592(C/A) 位置的启动子 SNP）的研究，这些多态性可能决定 IL-10 的产生，与 HCV 感染易感性、HCV 相关肝病（纤维化、肝硬化、肝细胞癌、ALT 异常）的病程、自发性病毒清除以及丙型肝炎治疗结果有关。对综述研究的分析表明，在开始抗 HCV 治疗之前，很难明确 IL-10 多态性作为丙型肝炎临床结果和对治疗反应的预测因子的重要性。因此，未来需要开展更大规模的研究来解决这些问题。继续研究白细胞介素 10 多态性以及鉴定 HCV 感染中的其他候选预测标志物具有重要的实际意义，有可能有助于减少丙型肝炎问题的规模。
