Babaei Amir Hossein, Foghaha Mahboube Haji
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
Iran J Nurs Midwifery Res. 2014 Mar;19(2):199-202.
Nausea and vomiting are the common symptoms of early pregnancy. Without treatment, vomiting can complicate the pregnancy, so it must be reduced. Wide varieties of treatment have been used for nausea and vomiting in pregnancy. This study compared the effectiveness of vitamin B6 and dimenhydrinate for gestational nausea and vomiting.
One hundred and forty pregnant women with a gestational age of <16 weeks who had symptoms of nausea and vomiting were selected. They were randomly allocated into group A (n = 70) and group B (n = 70). The patients in group A received a vitamin B6 tablet, while the patients in group B received a dimenhydrinate tablet daily; the tablets were identical in appearance. The degree of nausea and vomiting was assessed by physical symptoms of Rhodes score.
One hundred and thirty-five women returned to follow-up. Dimenhydrinate and vitamin B6 significantly reduced nausea and vomiting scores from 8.3 (7.4) to 2.8 (2.0) and from 8.6 (2.9) to 3.8 (2.3), respectively. The mean score change after treatment with dimenhydrinate was greater than with vitamin B6.
Both dimenhydrinate and vitamin B6 were effective in the treatment of nausea and vomiting in early pregnancy. Dimenhydrinate was more effective than vitamin B6.
恶心和呕吐是早孕的常见症状。若不治疗，呕吐会使妊娠复杂化，因此必须减轻呕吐症状。已采用多种治疗方法来治疗妊娠恶心和呕吐。本研究比较了维生素B6和茶苯海明治疗妊娠恶心和呕吐的有效性。
选取140例孕周<16周且有恶心和呕吐症状的孕妇。她们被随机分为A组（n = 70）和B组（n = 70）。A组患者每日服用一片维生素B6片，而B组患者每日服用一片茶苯海明片；两种片剂外观相同。通过罗兹评分的身体症状评估恶心和呕吐的程度。
135名女性返回接受随访。茶苯海明和维生素B6分别使恶心和呕吐评分从8.3（7.4）显著降至2.8（2.0）和从8.6（2.9）降至3.8（2.3）。茶苯海明治疗后的平均评分变化大于维生素B6。
茶苯海明和维生素B6在治疗早孕恶心和呕吐方面均有效。茶苯海明比维生素B6更有效。
