Department of Midwifery, Touyserkan University of Islamic Azad, Hamedan, Iran.
Midwifery. 2009 Dec;25(6):649-53. doi: 10.1016/j.midw.2007.10.013. Epub 2008 Feb 12.
to compare the effectiveness of ginger and vitamin B6 for the treatment of nausea and vomiting in early pregnancy.
double-blind randomised controlled trial. Pregnant women with nausea, who first attended the antenatal clinic at or before 17 weeks gestation, were invited to participate in the study. Over a 3-month period, 70 women were randomised to receive either ginger 1g/day or vitamin B6 40 mg/day for 4 days. Subjects graded the severity of their nausea using a visual analogue scale, and recorded the number of vomiting episodes in the 24 hours before treatment and during 4 consecutive days while taking treatment. At 7-day follow-up, women reported any changes in the severity of their symptoms.
compared with baseline, the decrease in the visual analogue scores of post-therapy nausea in the ginger group was significantly greater than that for the vitamin B6 group (p = 0.024). The number of vomiting episodes decreased in both groups, and there was no significant difference between the groups. In the ginger group, 29/35 women reported an improvement in nausea symptoms, compared with 23/34 women in the vitamin B6 group (p = 0.52).
ginger is more effective than vitamin B6 for relieving the severity of nausea, and is equally effective for decreasing the number of vomiting episodes in early pregnancy.
比较生姜和维生素 B6 治疗早孕恶心呕吐的疗效。
双盲随机对照试验。邀请在妊娠 17 周或之前首次到产前门诊就诊、伴有恶心的孕妇参加本研究。在 3 个月期间，70 名孕妇被随机分配接受生姜 1g/天或维生素 B6 40mg/天，连续治疗 4 天。采用视觉模拟评分法评估受试者恶心的严重程度，并记录治疗前 24 小时和治疗期间连续 4 天的呕吐次数。在 7 天随访时，报告妇女症状严重程度的任何变化。
与基线相比，生姜组治疗后恶心的视觉模拟评分下降显著大于维生素 B6 组（p=0.024）。两组的呕吐次数均减少，两组之间无显著差异。在生姜组，35 名妇女中有 29 名报告恶心症状改善，而在维生素 B6 组中，34 名妇女中有 23 名报告恶心症状改善（p=0.52）。
生姜在缓解恶心严重程度方面比维生素 B6 更有效，在减少早孕呕吐次数方面与维生素 B6 同样有效。
