Pourhoseingholi Mohamad Amin, Vahedi Mohsen, Rahimzadeh Mitra
Department of Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Gastroenterol Hepatol Bed Bench. 2013 Winter;6(1):14-7.
Optimum sample size is an essential component of any research. The main purpose of the sample size calculation is to determine the number of samples needed to detect significant changes in clinical parameters, treatment effects or associations after data gathering. It is not uncommon for studies to be underpowered and thereby fail to detect the existing treatment effects due to inadequate sample size. In this paper, we explain briefly the basic principles of sample size calculations in medical studies.
最佳样本量是任何研究的重要组成部分。样本量计算的主要目的是确定在收集数据后检测临床参数、治疗效果或关联的显著变化所需的样本数量。由于样本量不足，研究效能不足从而未能检测到现有治疗效果的情况并不少见。在本文中，我们简要解释医学研究中样本量计算的基本原理。
