医学研究中的样本量计算。
Sample size calculation in medical studies.
作者信息
Pourhoseingholi Mohamad Amin, Vahedi Mohsen, Rahimzadeh Mitra
机构信息
Department of Biostatistics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Gastroenterol Hepatol Bed Bench. 2013 Winter;6(1):14-7.
Abstract
Optimum sample size is an essential component of any research. The main purpose of the sample size calculation is to determine the number of samples needed to detect significant changes in clinical parameters, treatment effects or associations after data gathering. It is not uncommon for studies to be underpowered and thereby fail to detect the existing treatment effects due to inadequate sample size. In this paper, we explain briefly the basic principles of sample size calculations in medical studies.
摘要
最佳样本量是任何研究的重要组成部分。样本量计算的主要目的是确定在收集数据后检测临床参数、治疗效果或关联的显著变化所需的样本数量。由于样本量不足，研究效能不足从而未能检测到现有治疗效果的情况并不少见。在本文中，我们简要解释医学研究中样本量计算的基本原理。
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本文引用的文献
1
When calculation of minimum sample size is not justified: When sample size calculation is not justified.
Hepat Mon. 2011 Mar;11(3):208-9.
2
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Indian J Dermatol Venereol Leprol. 2004 Mar-Apr;70(2):123-8.
3
Sample size determination for research projects.
J Orthod. 2003 Jun;30(2):99-100. doi: 10.1093/ortho/30.2.99.
4
Specifying objectives and outcomes for clinical trials.
Med J Aust. 2002 May 20;176(10):491-2. doi: 10.5694/j.1326-5377.2002.tb04522.x.
5
The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" trials.
N Engl J Med. 1978 Sep 28;299(13):690-4. doi: 10.1056/NEJM197809282991304.
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