Nagornaia V F
Vopr Med Khim. 1989 Nov-Dec;35(6):73-7.
Activities of elastase and its inhibitors were studied in blood serum and tissues of patients with ovary benign tumors. Two peaks of the enzyme activation were detected during the menstrual cycle: at periovulatory period and at the second step of the cycle. In blood serum and tissues of the patients a decrease in the elastase activity was found, which was most distinct in papillary and mucinosis tumors. These alterations in the elastase activity appears to be responsible for impairments in the blood vessel wall structure, which may limit in penetration of estrogens into circulation and cause prolongation of effects of steroids on ovary tissue.
对卵巢良性肿瘤患者的血清和组织中的弹性蛋白酶及其抑制剂活性进行了研究。在月经周期中检测到该酶激活的两个峰值：在排卵期和周期的第二个阶段。在患者的血清和组织中发现弹性蛋白酶活性降低，这在乳头状和粘液化生性肿瘤中最为明显。弹性蛋白酶活性的这些改变似乎是血管壁结构受损的原因，这可能会限制雌激素进入循环，并导致类固醇对卵巢组织的作用延长。
