Albertini P, Amenta F, Bossoni G, Cavallotti C, Felici L, Ferrante F, Gaviraghi G
Department of Neurological Science, Università La Sapienza, Rome, Italy.
Drugs Exp Clin Res. 1989;15(9):421-7.
The effect of methylazoxymethanol (MAM), administered on the 15th gestational day, on the density and pattern of muscarinic cholinergic receptors in some brain areas was assessed using combined radioreceptor binding and autoradiographic techniques. The effect of 15 days' treatment with acetyl-L-carnitine on the same parameter was also assessed. The density of muscarinic cholinergic receptors was found to be increased in the brain of MAM-microencephalic rats. Acetyl-L-carnitine administration caused a significant reduction in the density of receptors under study. A possible role of acetyl-L-carnitine in restoring central cholinergic neurotransmission is discussed.
运用放射性受体结合与放射自显影技术相结合的方法，评估了在妊娠第15天给予甲基氧化偶氮甲醇（MAM）对某些脑区毒蕈碱型胆碱能受体密度和分布模式的影响。同时也评估了乙酰-L-肉碱15天治疗对同一参数的影响。结果发现，MAM致小头畸形大鼠脑内毒蕈碱型胆碱能受体密度增加。给予乙酰-L-肉碱导致所研究受体的密度显著降低。本文讨论了乙酰-L-肉碱在恢复中枢胆碱能神经传递中的可能作用。
