乙酰左旋肉碱治疗对甲基氧化偶氮甲醇致小脑发育不全大鼠脑核糖核酸水平的影响。

Effect of acetyl-L-carnitine treatment on brain ribonucleic acid levels in methylazoxymethanol-microencephalic rats.

作者信息

Albertini P, Amenta F, Bossoni G, Bronzetti E, Cavallotti C, Gaviraghi G

机构信息

Department of Neurological Science, Università La Sapienza, Rome, Italy.

出版信息

Drugs Exp Clin Res. 1989;15(9):429-34.

PMID:2483546

Abstract

The effects of methylazoxymethanol acetate (MAM) administered on the 15th gestational day, and of acetyl-L-carnitine treatment, on rat brain total and ribosomal RNA levels, were studied. In the brain of MAM-treated rats both total and ribosomal RNA concentrations were significantly reduced. Acetyl-L-carnitine treatment restored total and ribosomal RNA levels. The frontal cortex and the hippocampus were the brain areas most sensitive to acetyl-L-carnitine administration. Histochemical demonstration of tissue stores of nucleic acids showed that the loss of RNA induced by MAM occurs primarily within the cytoplasm of nerve cells in various telencephalic areas. Neuronal cytoplasmatic RNA is also sensitive to acetyl-L-carnitine treatment.

摘要

研究了在妊娠第15天给予醋酸甲基偶氮甲醇（MAM）以及乙酰-L-肉碱处理对大鼠脑总RNA和核糖体RNA水平的影响。在经MAM处理的大鼠脑中，总RNA和核糖体RNA浓度均显著降低。乙酰-L-肉碱处理可恢复总RNA和核糖体RNA水平。额叶皮质和海马体是对乙酰-L-肉碱给药最敏感的脑区。核酸组织储存的组织化学证明表明，MAM诱导的RNA损失主要发生在各个端脑区域神经细胞的细胞质内。神经元细胞质RNA对乙酰-L-肉碱处理也敏感。