Baksi A, Edwards J S
St. Marys Hospital, Newport, Isle of Wight, England.
J Cardiovasc Pharmacol. 1989;14 Suppl 10:S33-5; discussion S59-62.
The acute and short-term pharmacokinetics of the calcium antagonist nitrendipine were investigated in 18 elderly subjects (9 healthy volunteers and 9 hypertensive patients). The subjects received nitrendipine 10 mg twice daily for 7 days and the pharmacokinetics profiles for days 1 and 7 were compared for evidence of drug accumulation. In the healthy volunteers, neither the area under the curve (AUC) nor Cmax were significantly affected by nitrendipine treatment, although T1/2 was significantly increased on day 7. In the hypertensive patients, AUC was higher on day 7 than day 1, although this was only marginally significant (p = 0.050); Cmax and T1/2 were unchanged. Nitrendipine significantly reduced both systolic and diastolic blood pressure in the hypertensive patients but had no effect on the blood pressure of the healthy normotensive volunteers. Nitrendipine does not appear to accumulate significantly when given twice daily to elderly volunteers and hypertensive patients.
在18名老年受试者（9名健康志愿者和9名高血压患者）中研究了钙拮抗剂尼群地平的急性和短期药代动力学。受试者每日两次服用10毫克尼群地平，共7天，并比较第1天和第7天的药代动力学曲线，以证明药物蓄积情况。在健康志愿者中，尽管第7天的半衰期显著延长，但尼群地平治疗对曲线下面积（AUC）和最大血药浓度（Cmax）均无显著影响。在高血压患者中，第7天的AUC高于第1天，尽管这仅具有边缘显著性（p = 0.050）；Cmax和半衰期未发生变化。尼群地平显著降低了高血压患者的收缩压和舒张压，但对健康血压正常的志愿者的血压没有影响。当每日两次给予老年志愿者和高血压患者时，尼群地平似乎不会显著蓄积。
