抗生素耐药性的可逆转性。
Reversibility of antibiotic resistance.
机构信息
Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital , Örebro , Sweden.
出版信息
Ups J Med Sci. 2014 May;119(2):142-8. doi: 10.3109/03009734.2014.903323.
Abstract
Although theoretically attractive, the reversibility of resistance has proven difficult in practice, even though antibiotic resistance mechanisms induce a fitness cost to the bacterium. Associated resistance to other antibiotics and compensatory mutations seem to ameliorate the effect of antibiotic interventions in the community. In this paper the current understanding of the concepts of reversibility of antibiotic resistance and the interventions performed in hospitals and in the community are reviewed.
摘要
尽管从理论上讲很有吸引力，但耐药性的可逆转性在实践中证明是困难的，尽管抗生素耐药机制会给细菌带来适应性成本。对其他抗生素的相关耐药性和补偿性突变似乎减轻了抗生素干预在社区中的效果。本文回顾了目前对抗生素耐药性可逆转性概念的理解，以及在医院和社区中进行的干预措施。
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