Khomeriki S G
Arkh Anat Gistol Embriol. 1989 Nov;97(11):64-9.
In the gastric mucosal membrane of rats--mature, first old and late old age (9.5-20, 26.5-29 and 32.5-37 months) ultrastructure of serotonin-producing EC-cells and histamine-producing ECL-cells has been studied. By means of stereomorphometric methods volumes of nuclei, nucleoli, cytoplasm and its organelles, nuclear cytoplasmic index, amount of endocrine granules have been determined. Increasing volumes of EC- and ECL-cells and their organelles in the old age demonstrate certain development of adaptive changes, directed to maintenance of monoamines secretion at a necessary level. This is reached at the expense of increasing energetic and plastic expenditure. In the late old age intensification of adaptation, further growth of organelles volumes, responsible for energetic and plastic metabolism are kept for EC-cells. Increasing content of active granules in cytoplasm demonstrates an enhanced production of serotonin by every separate cells. In the same age in ECL-cells the adaptive processes decrease. Volumes of the cells and their all organelles sharply drops, the number of the active granules decreases; this should result in decreasing histamine production in the gastric mucous membrane.
对成熟、初老和老龄（9.5 - 20、26.5 - 29和32.5 - 37个月）大鼠胃黏膜中产生5-羟色胺的肠嗜铬（EC）细胞和产生组胺的肠嗜铬样（ECL）细胞的超微结构进行了研究。通过立体形态计量学方法，测定了细胞核、核仁、细胞质及其细胞器的体积、核质指数、内分泌颗粒数量。老龄时EC细胞和ECL细胞及其细胞器体积增加，表明适应性变化有一定发展，旨在将单胺分泌维持在必要水平。这是以增加能量和物质消耗为代价实现的。在老龄后期，EC细胞维持适应性增强，负责能量和物质代谢的细胞器体积进一步增大。细胞质中活性颗粒含量增加表明每个单独细胞的5-羟色胺产生增强。在同一年龄，ECL细胞中的适应性过程减弱。细胞及其所有细胞器的体积急剧下降，活性颗粒数量减少；这将导致胃黏膜中组胺产生减少。
