Kaiser B
Institut für Pharmakologie und Toxikologie, Medizinischen Akademie Erfurt.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1989;116(6):841-9.
A review about comprehensive studies on pharmacological properties of hirudin produced by genetic engineering is given. Anticoagulant effects, influence on platelet functions, studies on toxicity and side effects as well as the pharmacokinetic behaviour and antithrombotic actions of this highly effective thrombin inhibitor are described.