Liu Fu-Chao, Chuang Yueh-Hsun, Tsai Yung-Fong, Yu Huang-Ping
*Department of Anesthesiology, Chang Gung Memorial Hospital; and †College of Medicine, Chang Gung University, Taoyuan; and ‡Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan.
Shock. 2014 Jun;41(6):491-8. doi: 10.1097/SHK.0000000000000146.
Neutrophil extracellular traps (NETs), which consist of neutrophil DNA and cytoplasmic proteins, have been shown to be involved in various infectious, inflammatory, and autoimmune diseases. Neutrophil extracellular traps are abundant at the site of infection and acute inflammation. Neutrophil extracellular trap formation can occur through various intracellular signaling pathways, including peptidylarginine deiminase 4, Raf-MEK-ERK, nitric oxide, Toll-like receptor 4, high mobility group box 1, pentraxin 3, and mammalian targets of rapamycin. A growing body of evidence indicates that NETs may play an important role in injury, and decreases in NETs could reduce tissue injury. Neutrophil extracellular traps are believed to modulate the inflammatory and immune responses of individuals after injury. In this review, the role of NETs in injury, including traumatic injury, ischemia-reperfusion-induced injury, and sepsis, as well as the potential markers and therapeutic targets of NET-related injury will be discussed.
中性粒细胞胞外诱捕网（NETs）由中性粒细胞DNA和细胞质蛋白组成，已被证明参与多种感染性、炎症性和自身免疫性疾病。中性粒细胞胞外诱捕网在感染和急性炎症部位大量存在。中性粒细胞胞外诱捕网的形成可通过多种细胞内信号通路发生，包括肽基精氨酸脱氨酶4、Raf-MEK-ERK、一氧化氮、Toll样受体4、高迁移率族蛋白B1、五聚素3和雷帕霉素的哺乳动物靶点。越来越多的证据表明，NETs可能在损伤中起重要作用，NETs的减少可能会减轻组织损伤。中性粒细胞胞外诱捕网被认为可调节个体受伤后的炎症和免疫反应。在这篇综述中，将讨论NETs在损伤中的作用，包括创伤性损伤、缺血再灌注诱导的损伤和脓毒症，以及NET相关损伤的潜在标志物和治疗靶点。
