Carriles Yaquelin Ramos, Brito Rubén Alvarez, Sánchez Ricardo Martínez, Acevedo Elayma Sánchez, Domínguez Paola Rodríguez, Mueller Wolf-Dieter
Chemistry-Physics Department, Faculty of Chemistry, University of Havana, Zapata and G, Vedado, Havana 10400, Cuba.
Polymers Laboratory, IMRE, University of Havana, Zapata and G, Vedado, Havana 10400, Cuba.
Molecules. 2014 May 15;19(5):6220-7. doi: 10.3390/molecules19056220.
Alkyl cyanoacrylates are interesting products for use in industry because of their properties enabling them to stick together a wide range of substrates. n-Butyl cyanoacrylate is one of the most successfully used tissue adhesives in the field of medicine because it exhibits bacteriostatic and haemostatic characteristics, in addition to its adhesive properties. At present, its synthesis is performed with good yields via Knoevenagel condensation using conventional sources of heating, but this requires a long processing time. The aim of this work was to look for a new way of synthesising n-butyl cyanoacrylate using microwave irradiation as the source of heating. This non-conventional source of heating most likely reduces the process time of the synthesis. In comparison with a conventional heating source, such as an oil bath, the results showed the advantages of this method whereby the n-butyl cyanoacrylate gave the same yield and quality with a reduction in the reaction time by a factor of 3-5-fold.
氰基丙烯酸烷基酯因其能够将多种基材粘合在一起的特性而成为工业上有趣的产品。氰基丙烯酸正丁酯是医学领域最成功使用的组织粘合剂之一，因为它除了具有粘合性能外，还具有抑菌和止血特性。目前，其合成通过使用传统加热源的克诺文格尔缩合反应以良好的产率进行，但这需要较长的处理时间。这项工作的目的是寻找一种使用微波辐射作为加热源来合成氰基丙烯酸正丁酯的新方法。这种非常规加热源很可能会缩短合成过程的时间。与传统加热源（如油浴）相比，结果显示了该方法的优势，即氰基丙烯酸正丁酯在反应时间缩短3至5倍的情况下仍能获得相同的产率和质量。
