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变铅青链霉菌中可诱导的核糖体RNA甲基化赋予对林可霉素的抗性。

Inducible ribosomal RNA methylation in Streptomyces lividans, conferring resistance to lincomycin.

作者信息

Jenkins G, Zalacain M, Cundliffe E

机构信息

Department of Biochemistry and Leicester Biocentre, University of Leicester, UK.

出版信息

J Gen Microbiol. 1989 Dec;135(12):3281-8. doi: 10.1099/00221287-135-12-3281.

DOI:10.1099/00221287-135-12-3281
PMID:2483994
Abstract

Streptomyces lividans TK21 possesses inducible ribosomal RNA methylase activity that confers high-level resistance to lincomycin and lower levels of resistance to certain macrolides. The methylase gene (designated lrm) is inducible by erythromycin and other macrolides and also by celesticetin (a lincosamide) but not by lincomycin. The lrm enzyme monomethylates the N6-amino group of adenosine at position 2058 within 23S-like ribosomal RNA.

摘要

变铅青链霉菌TK21具有可诱导的核糖体RNA甲基化酶活性，该活性赋予对林可霉素的高水平抗性以及对某些大环内酯类的较低水平抗性。甲基化酶基因（命名为lrm）可被红霉素和其他大环内酯类诱导，也可被天青菌素（一种林可酰胺类）诱导，但不能被林可霉素诱导。lrm酶使23S样核糖体RNA中第2058位腺苷的N6-氨基发生单甲基化。

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Inducible ribosomal RNA methylation in Streptomyces lividans, conferring resistance to lincomycin.变铅青链霉菌中可诱导的核糖体RNA甲基化赋予对林可霉素的抗性。
J Gen Microbiol. 1989 Dec;135(12):3281-8. doi: 10.1099/00221287-135-12-3281.
2
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