Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Small. 2014 Sep 24;10(18):3655-61. doi: 10.1002/smll.201400612. Epub 2014 May 20.
Nerve regeneration is of diagnostic importance in neuroscience in regards to the treatment of degenerative disease. Owing to the ability to release rare-earth ions and produce ROS during upconversion process, upconversion nanoparticles are first reported for promoting neurite outgrowth. Different charged coating materials which play a critical role in cell attachment, can further lead to different effects on cell differentiation.
神经再生在神经科学中具有重要的诊断意义，与退行性疾病的治疗有关。上转换纳米粒子在转化过程中由于能够释放稀土离子和产生 ROS，因此首先被报道用于促进神经突生长。不同带电的涂层材料在上转换纳米粒子表面，在上转换纳米粒子与细胞的相互作用中发挥着重要作用，进一步导致对细胞分化的不同影响。
