University of Illinois Urbana-Champaign, Department of Kinesiology and Community Health, Urbana, IL, USA.
University of Illinois Urbana-Champaign, Department of Kinesiology and Community Health, Urbana, IL, USA.
J Psychosom Res. 2014 Jun;76(6):465-71. doi: 10.1016/j.jpsychores.2014.03.014. Epub 2014 Mar 31.
There is a high prevalence, yet under-treatment of depressive disorder and symptoms by conventional therapy in people with multiple sclerosis (MS). We conducted a meta-analysis examining the overall effect of exercise training on depressive symptoms in MS.
We searched PubMed for randomized controlled trials (RCT) of exercise training and depression as an outcome in samples with MS. There were 13 RCTs that met inclusion criteria and yielded data for effect size (ES) generation (Cohen's d). An overall ES was calculated using a random effects model and expressed as Hedge's g.
The weighted mean ES was small, but statistically significant (Hedge's g=0.36, SE=0.09, 95% CI=0.18-0.54, z=3.92, p<.001) indicating the exercise training resulted in an improvement in depressive symptoms compared to control. The overall effect was not heterogeneous (Q=16.46, df=12, p=0.17, I2=27.08); and post-hoc, exploratory analyses only identified depression symptom scale as a potential moderator variable (p=0.04).
The cumulative evidence indicates that exercise training can yield a small, yet statistically significant and reliable reduction in depressive symptoms for people with MS.
多发性硬化症（MS）患者中，常规治疗对抑郁障碍和症状的治疗率高，但治疗不足。我们进行了一项荟萃分析，以评估运动训练对 MS 患者抑郁症状的总体影响。
我们在 PubMed 中搜索了运动训练和抑郁作为 MS 患者结局的随机对照试验（RCT）。有 13 项 RCT 符合纳入标准，并产生了用于生成效应量（ES）的数据（Cohen's d）。使用随机效应模型计算总体 ES，并表示为 Hedge's g。
加权平均 ES 虽然较小，但具有统计学意义（Hedge's g=0.36，SE=0.09，95%CI=0.18-0.54，z=3.92，p<.001），表明与对照组相比，运动训练可改善抑郁症状。总体效应无异质性（Q=16.46，df=12，p=0.17，I2=27.08）；事后探索性分析仅发现抑郁症状量表是潜在的调节变量（p=0.04）。
累积证据表明，运动训练可使 MS 患者的抑郁症状得到微小但具有统计学意义和可靠的降低。
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