Fu Ying, Zhu Wenbo, Zhao Xingling, Hügel Helmut, Wu Zhouqiang, Su Yuhu, Du Zhengyin, Huang Danfeng, Hu Yulai
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, PR China.
Org Biomol Chem. 2014 Jul 7;12(25):4295-9. doi: 10.1039/c4ob00638k.
In this study, a facile CuI catalyzed synthesis of sulfones involving a nucleophilic addition of functionalized organozinc reagents to organic sulfonyl chlorides is realized. This reaction proceeds efficiently at room temperature, giving rise to various functional group substituted sulfones, generally in moderate to high yields. The method provides a novel, simple, and promising strategy for functionalized sulfone synthesis in the research field of sulfur chemistry.
在本研究中，实现了一种简便的碘化亚铜催化的砜类化合物的合成方法，该方法涉及官能化有机锌试剂对有机磺酰氯的亲核加成反应。此反应在室温下能高效进行，可生成各种官能团取代的砜类化合物，产率通常为中等至较高。该方法为硫化学研究领域中官能化砜的合成提供了一种新颖、简便且有前景的策略。
